Please use this identifier to cite or link to this item: https://doi.org/10.3390/biom10071040
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dc.titleMicroRNAs and their influence on the zeb family: Mechanistic aspects and therapeutic applications in cancer therapy
dc.contributor.authorAshrafizadeh, M.
dc.contributor.authorAng, H.L.
dc.contributor.authorMoghadam, E.R.
dc.contributor.authorMohammadi, S.
dc.contributor.authorZarrin, V.
dc.contributor.authorHushmandi, K.
dc.contributor.authorSamarghandian, S.
dc.contributor.authorZarrabi, A.
dc.contributor.authorNajafi, M.
dc.contributor.authorMohammadinejad, R.
dc.contributor.authorKumar, A.P.
dc.date.accessioned2021-08-23T03:13:10Z
dc.date.available2021-08-23T03:13:10Z
dc.date.issued2020-07-12
dc.identifier.citationAshrafizadeh, M., Ang, H.L., Moghadam, E.R., Mohammadi, S., Zarrin, V., Hushmandi, K., Samarghandian, S., Zarrabi, A., Najafi, M., Mohammadinejad, R., Kumar, A.P. (2020-07-12). MicroRNAs and their influence on the zeb family: Mechanistic aspects and therapeutic applications in cancer therapy. Biomolecules 10 (7) : 1-45. ScholarBank@NUS Repository. https://doi.org/10.3390/biom10071040
dc.identifier.issn2218273X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/198603
dc.description.abstractMolecular signaling pathways involved in cancer have been intensively studied due to their crucial role in cancer cell growth and dissemination. Among them, zinc finger E-box binding homeobox-1 (ZEB1) and-2 (ZEB2) are molecules that play vital roles in signaling pathways to ensure the survival of tumor cells, particularly through enhancing cell proliferation, promoting cell migration and invasion, and triggering drug resistance. Importantly, ZEB proteins are regulated by microRNAs (miRs). In this review, we demonstrate the impact that miRs have on cancer therapy, through their targeting of ZEB proteins. MiRs are able to act as onco-suppressor factors and inhibit the malignancy of tumor cells through ZEB1/2 down-regulation. This can lead to an inhibition of epithelial-mesenchymal transition (EMT) mechanism, therefore reducing metastasis. Additionally, miRs are able to inhibit ZEB1/2-mediated drug resistance and immunosuppression. Additionally, we explore the upstream modulators of miRs such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), as these regulators can influence the inhibitory effect of miRs on ZEB proteins and cancer progression. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2020
dc.subjectCancer therapy
dc.subjectDrug resistance
dc.subjectEMT
dc.subjectImmunotherapy
dc.subjectMicroRNA
dc.subjectNon-coding RNA
dc.subjectZEB family
dc.typeArticle
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.3390/biom10071040
dc.description.sourcetitleBiomolecules
dc.description.volume10
dc.description.issue7
dc.description.page1-45
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