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https://doi.org/10.1038/s41467-020-14543-2
DC Field | Value | |
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dc.title | Versatile cobalt-catalyzed regioselective chain-walking double hydroboration of 1,n-dienes to access gem-bis(boryl)alkanes | |
dc.contributor.author | Hu, M. | |
dc.contributor.author | Ge, S. | |
dc.date.accessioned | 2021-08-19T04:37:30Z | |
dc.date.available | 2021-08-19T04:37:30Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Hu, M., Ge, S. (2020). Versatile cobalt-catalyzed regioselective chain-walking double hydroboration of 1,n-dienes to access gem-bis(boryl)alkanes. Nature Communications 11 (1) : 765. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-14543-2 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/198124 | |
dc.description.abstract | Double hydroboration of dienes is the addition of a hydrogen and a boryl group to the two double bonds of a diene molecule and represents a straightforward and effective protocol to prepare synthetically versatile bis(boryl)alkanes, provided that this reaction occurs selectively. However, this reaction can potentially yield several isomeric organoboron products, and it still remains a challenge to control the regioselectivity of this reaction, which allows the selective production of a single organoboron product, in particular, for a broad scope of dienes. By employing a readily available cobalt catalyst, here we show that this double hydroboration yields synthetically useful gem-bis(boryl)alkanes with excellent regioselectivity. In addition, the scope of dienes for this reaction is broad and encompasses a wide range of conjugated and non-conjugated dienes. Furthermore, mechanistic studies indicate that this cobalt-catalyzed double hydroboration occurs through boryl-directed chain-walking hydroboration of alkenylboronates generated from anti-Markovnikov 1,2-hydroboration of 1,n-diene. © 2020, The Author(s). | |
dc.publisher | Nature Research | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2020 | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1038/s41467-020-14543-2 | |
dc.description.sourcetitle | Nature Communications | |
dc.description.volume | 11 | |
dc.description.issue | 1 | |
dc.description.page | 765 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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