Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-020-16180-1
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dc.titleChromosome-level assembly of the horseshoe crab genome provides insights into its genome evolution
dc.contributor.authorShingate, P.
dc.contributor.authorRavi, V.
dc.contributor.authorPrasad, A.
dc.contributor.authorTay, B.-H.
dc.contributor.authorGarg, K.M.
dc.contributor.authorChattopadhyay, B.
dc.contributor.authorYap, L.-M.
dc.contributor.authorRheindt, F.E.
dc.contributor.authorVenkatesh, B.
dc.date.accessioned2021-08-19T04:37:19Z
dc.date.available2021-08-19T04:37:19Z
dc.date.issued2020
dc.identifier.citationShingate, P., Ravi, V., Prasad, A., Tay, B.-H., Garg, K.M., Chattopadhyay, B., Yap, L.-M., Rheindt, F.E., Venkatesh, B. (2020). Chromosome-level assembly of the horseshoe crab genome provides insights into its genome evolution. Nature Communications 11 (1) : 2322. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-020-16180-1
dc.identifier.issn2041-1723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/198121
dc.description.abstractThe evolutionary history of horseshoe crabs, spanning approximately 500 million years, is characterized by remarkable morphological stasis and a low species diversity with only four extant species. Here we report a chromosome-level genome assembly for the mangrove horseshoe crab (Carcinoscorpius rotundicauda) using PacBio reads and Hi-C data. The assembly spans 1.67 Gb with contig N50 of 7.8 Mb and 98% of the genome assigned to 16 chromosomes. The genome contains five Hox clusters with 34 Hox genes, the highest number reported in any invertebrate. Detailed analysis of the genome provides evidence that suggests three rounds of whole-genome duplication (WGD), raising questions about the relationship between WGD and species radiation. Several gene families, particularly those involved in innate immunity, have undergone extensive tandem duplication. These expanded gene families may be important components of the innate immune system of horseshoe crabs, whose amebocyte lysate is a sensitive agent for detecting endotoxin contamination. © 2020, The Author(s).
dc.publisherNature Research
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2020
dc.typeArticle
dc.contributor.departmentDEPT OF BIOLOGICAL SCIENCES
dc.description.doi10.1038/s41467-020-16180-1
dc.description.sourcetitleNature Communications
dc.description.volume11
dc.description.issue1
dc.description.page2322
dc.published.statePublished
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