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https://doi.org/10.1016/j.ebiom.2020.102768
Title: | Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development | Authors: | de Alwis, R. Chen, S. Gan, E.S. Ooi, E.E. |
Keywords: | Coronavirus COVID-19 Polyclonal hyperimmune globulin SARS-CoV-2 Vaccines |
Issue Date: | 2020 | Publisher: | Elsevier B.V. | Citation: | de Alwis, R., Chen, S., Gan, E.S., Ooi, E.E. (2020). Impact of immune enhancement on Covid-19 polyclonal hyperimmune globulin therapy and vaccine development. EBioMedicine 55 : 102768. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ebiom.2020.102768 | Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International | Abstract: | The pandemic spread of a novel coronavirus – SARS coronavirus-2 (SARS-CoV-2) as a cause of acute respiratory illness, named Covid-19, is placing the healthcare systems of many countries under unprecedented stress. Global economies are also spiraling towards a recession in fear of this new life-threatening disease. Vaccines that prevent SARS-CoV-2 infection and therapeutics that reduces the risk of severe Covid-19 are thus urgently needed. A rapid method to derive antiviral treatment for Covid-19 is the use of convalescent plasma derived hyperimmune globulin. However, both hyperimmune globulin and vaccine development face a common hurdle – the risk of antibody-mediated disease enhancement. The goal of this review is to examine the body of evidence supporting the hypothesis of immune enhancement that could be pertinent to Covid-19. We also discuss how this risk could be mitigated so that both hyperimmune globulin and vaccines could be rapidly translated to overcome the current global health crisis. © 2020 The Author(s) | Source Title: | EBioMedicine | URI: | https://scholarbank.nus.edu.sg/handle/10635/197902 | ISSN: | 2352-3964 | DOI: | 10.1016/j.ebiom.2020.102768 | Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International |
Appears in Collections: | Elements Staff Publications |
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