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|Title:||A supramolecular platform for controlling and optimizing molecular architectures of siRNA targeted delivery vehicles||Authors:||Wen, Y.
|Issue Date:||2020||Publisher:||American Association for the Advancement of Science||Citation:||Wen, Y., Bai, H., Zhu, J., Song, X., Tang, G., Li, J. (2020). A supramolecular platform for controlling and optimizing molecular architectures of siRNA targeted delivery vehicles. Science Advances 6 (31) : eabc2148. ScholarBank@NUS Repository. https://doi.org/10.1126/sciadv.abc2148||Rights:||Attribution-NonCommercial 4.0 International||Abstract:||It requires multistep synthesis and conjugation processes to incorporate multifunctionalities into a polyplex gene vehicle to overcome numerous hurdles during gene delivery. Here, we describe a supramolecular platform to precisely control, screen, and optimize molecular architectures of siRNA targeted delivery vehicles, which is based on rationally designed host-guest complexation between a ?-cyclodextrin朾ased cationic host polymer and a library of guest polymers with various PEG shape and size, and various density of ligands. The host polymer is responsible to load/unload siRNA, while the guest polymer is responsible to shield the vehicles from nonspecific cellular uptake, to prolong their circulation time, and to target tumor cells. A series of precisely controlled molecular architectures through a simple assembly process allow for a rapid optimization of siRNA delivery vehicles in vitro and in vivo for therapeutic siRNA-Bcl2 delivery and tumor therapy, indicating the platform is a powerful screening tool for targeted gene delivery vehicles. Copyright � 2020 The Authors, some rights reserved.||Source Title:||Science Advances||URI:||https://scholarbank.nus.edu.sg/handle/10635/197683||ISSN:||23752548||DOI:||10.1126/sciadv.abc2148||Rights:||Attribution-NonCommercial 4.0 International|
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