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https://doi.org/10.1136/bmjdrc-2019-001051
Title: | Tissue inhibitor matrix metalloproteinase 1 and risk of type 2 diabetes in a Chinese population | Authors: | Wang, Y. Yuan, J.-M. Pan, A. Koh, W.-P. |
Keywords: | epidemiology type 2 diabetes |
Issue Date: | 2020 | Publisher: | BMJ Publishing Group | Citation: | Wang, Y., Yuan, J.-M., Pan, A., Koh, W.-P. (2020). Tissue inhibitor matrix metalloproteinase 1 and risk of type 2 diabetes in a Chinese population. BMJ Open Diabetes Research and Care 8 (1) : e001051. ScholarBank@NUS Repository. https://doi.org/10.1136/bmjdrc-2019-001051 | Rights: | Attribution-NonCommercial 4.0 International | Abstract: | Introduction The non-invasive enhanced liver fibrosis (ELF) score - comprising tissue inhibitor of matrix metalloproteinases-1 (TIMP1), hyaluronic acid (HA) and amino-terminal propeptide of type III procollagen (PIIINP) - has been shown to accurately predict fibrosis stages among patients with non-alcoholic fatty liver disease (NAFLD). However, no study has examined whether the ELF score or its components would also be predictive of type 2 diabetes, which commonly coexists and shares the same pathogenic abnormalities with NAFLD. Therefore, we prospectively investigated their associations with type 2 diabetes risks for the first time. Research design and methods The ELF score was measured among 254 type 2 diabetes cases and 254 age-matched and sex-matched controls nested within the prospective Singapore Chinese Health Study. Cases had hemoglobin A1c (HbA1c) levels <6.5% at blood collection (1999-2004) and reported to have diabetes during follow-up II (2006-2010). Controls had HbA1c levels <6.0% at blood-taking and remained free of diabetes at follow-up II. Multivariable conditional logistic regression models were used to assess the ELF-diabetes association. Results Higher TIMP1 levels were associated with increased type 2 diabetes risk, and the OR comparing the highest versus lowest quartiles was 2.56 (95% CI 1.23 to 5.34; p trend=0.035). However, ELF score, PIIINP and HA were not significantly associated with type 2 diabetes risks. Conclusions Higher TIMP1 levels, but not ELF score, PIIIMP and HA, were associated with increased type 2 diabetes risk in Chinese adults. Our results suggested that elevated TIMP1 levels may contribute to the type 2 diabetes development through pathways other than liver fibrosis. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | Source Title: | BMJ Open Diabetes Research and Care | URI: | https://scholarbank.nus.edu.sg/handle/10635/196680 | ISSN: | 20524897 | DOI: | 10.1136/bmjdrc-2019-001051 | Rights: | Attribution-NonCommercial 4.0 International |
Appears in Collections: | Staff Publications Elements |
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