Please use this identifier to cite or link to this item: https://doi.org/10.3389/fendo.2020.00335
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dc.titleCumulative Risk on Oxytocin-Pathway Genes Impairs Default Mode Network Connectivity in Trauma-Exposed Youth
dc.contributor.authorZeev-Wolf, M.
dc.contributor.authorLevy, J.
dc.contributor.authorEbstein, R.P.
dc.contributor.authorFeldman, R.
dc.date.accessioned2021-08-11T06:28:13Z
dc.date.available2021-08-11T06:28:13Z
dc.date.issued2020
dc.identifier.citationZeev-Wolf, M., Levy, J., Ebstein, R.P., Feldman, R. (2020). Cumulative Risk on Oxytocin-Pathway Genes Impairs Default Mode Network Connectivity in Trauma-Exposed Youth. Frontiers in Endocrinology 11 : 335. ScholarBank@NUS Repository. https://doi.org/10.3389/fendo.2020.00335
dc.identifier.issn16642392
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/196590
dc.description.abstractBackground: Although the default mode network (DMN) is a core network essential for brain functioning, little is known about its developmental trajectory, particularly on factors associated with its coherence into a functional network. In light of adult studies indicating DMN's susceptibility to stress-related conditions, we examined links between variability on oxytocin-pathway genes and DMN connectivity in youth exposed to chronic war-related trauma Methods: Following a cohort of war-exposed children from early childhood, we imaged the brains of 74 preadolescents (age 11–13 years; 39 war-exposed) during rest using magnetoencephalography (MEG). A cumulative risk index on oxytocin-pathway genes was constructed by combining single nucleotide polymorphisms on five genes previously linked with social deficits and psychopathology; OXTR rs1042778, OXTR rs2254298, OXTRrs53576, CD38 rs3796863, and AVPR1A RS3. Avoidant response to trauma reminders in early childhood and anxiety disorders in late childhood were assessed as predictors of disruptions to DMN theta connectivity. Results: Higher vulnerability on oxytocin-pathway genes predicted greater disruptions to DMN theta connectivity. Avoidant symptoms in early childhood and generalized anxiety disorder in later childhood were related to impaired DMN connectivity. In combination, stress exposure, oxytocin-pathway genes, and stress-related symptoms explained 24.6% of the variance in DMN connectivity, highlighting the significant effect of stress on the maturing brain. Conclusions: Findings are the first to link the oxytocin system and maturation of the DMN, a core system sustaining autobiographical memories, alteration of intrinsic and extrinsic attention, mentalization, and sense of self. Results suggest that oxytocin may buffer the effects of chronic early stress on the DMN, particularly theta rhythms that typify the developing brain. © Copyright © 2020 Zeev-Wolf, Levy, Ebstein and Feldman.
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2020
dc.subjectanxiety disorders
dc.subjectgenetics
dc.subjectlongitudinal studies
dc.subjectmagnetoencephalography
dc.subjectOXTR
dc.subjecttrauma exposure
dc.typeArticle
dc.contributor.departmentPSYCHOLOGY
dc.description.doi10.3389/fendo.2020.00335
dc.description.sourcetitleFrontiers in Endocrinology
dc.description.volume11
dc.description.page335
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