Please use this identifier to cite or link to this item: https://doi.org/10.7150/jca.34847
DC FieldValue
dc.titleThe antipsychotic agent sertindole exhibited antiproliferative activities by inhibiting the STAT3 signaling pathway in human gastric cancer cells
dc.contributor.authorDai, C.
dc.contributor.authorLiu, P.
dc.contributor.authorWang, X.
dc.contributor.authorYin, Y.
dc.contributor.authorJin, W.
dc.contributor.authorShen, L.
dc.contributor.authorChen, Y.
dc.contributor.authorChen, Z.
dc.contributor.authorWang, Y.
dc.date.accessioned2021-08-10T03:08:06Z
dc.date.available2021-08-10T03:08:06Z
dc.date.issued2020
dc.identifier.citationDai, C., Liu, P., Wang, X., Yin, Y., Jin, W., Shen, L., Chen, Y., Chen, Z., Wang, Y. (2020). The antipsychotic agent sertindole exhibited antiproliferative activities by inhibiting the STAT3 signaling pathway in human gastric cancer cells. Journal of Cancer 11 (4) : 849-857. ScholarBank@NUS Repository. https://doi.org/10.7150/jca.34847
dc.identifier.issn1837-9664
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/196259
dc.description.abstractGastric cancer (GC) is the third leading cause of cancer-related death. Although the therapeutic approaches have improved, the 5-year survival rate of GC patients after surgical resection remains low due to the high rates of metastasis and recurrence. Patients with schizophrenia have significantly lower incidences of cancer after long-term drug treatment, suggesting the potential or partially ameliorate the risk of cancer development of antipsychotic drugs. The goal of this study was to explore antipsychotic drugs with an optional effective therapy against gastric cellular carcinoma. We found that sertindole, an atypical antipsychotic, exhibited anti-tumor efficacy on human GC cells in vitro and in vivo. Moreover, sertindole in combination with cisplatin dramatically enhanced apoptosis-induction in GC cells. In addition, the pro-apoptotic effect of sertindole on GC might in part, involved in inhibition of STAT3 activation and downstream signals, including Mcl1, surviving, c-Myc, cyclin D1. Collectively, these results suggested that sertindole could be a potential anticancer reagent and be an attractive therapeutic adjuvant for the treatment of human GC. © The author(s).
dc.publisherIvyspring International Publisher
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2020
dc.subjectCell apoptosis
dc.subjectCisplatin
dc.subjectGastric cancer
dc.subjectSertindole
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.7150/jca.34847
dc.description.sourcetitleJournal of Cancer
dc.description.volume11
dc.description.issue4
dc.description.page849-857
Appears in Collections:Elements
Staff Publications

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_7150_jca_34847.pdf1.41 MBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons