Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fphar.2020.00305
DC Field | Value | |
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dc.title | Clinical Efficacy Evaluation of 1-Year Subcutaneous Immunotherapy for Artemisia sieversiana Pollen Allergic Rhinitis by Serum Metabolomics | |
dc.contributor.author | Shi, H.-Y. | |
dc.contributor.author | Pan, C. | |
dc.contributor.author | Ma, T.-T. | |
dc.contributor.author | Chen, Y.-L. | |
dc.contributor.author | Yan, W.-J. | |
dc.contributor.author | Liu, J.-G. | |
dc.contributor.author | Cao, M.-D. | |
dc.contributor.author | Huang, H.-D. | |
dc.contributor.author | Wang, D.-Y. | |
dc.contributor.author | Wang, X.-Y. | |
dc.contributor.author | Wei, J.-F. | |
dc.date.accessioned | 2021-08-10T03:03:54Z | |
dc.date.available | 2021-08-10T03:03:54Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Shi, H.-Y., Pan, C., Ma, T.-T., Chen, Y.-L., Yan, W.-J., Liu, J.-G., Cao, M.-D., Huang, H.-D., Wang, D.-Y., Wang, X.-Y., Wei, J.-F. (2020). Clinical Efficacy Evaluation of 1-Year Subcutaneous Immunotherapy for Artemisia sieversiana Pollen Allergic Rhinitis by Serum Metabolomics. Frontiers in Pharmacology 11 : 305. ScholarBank@NUS Repository. https://doi.org/10.3389/fphar.2020.00305 | |
dc.identifier.issn | 1663-9812 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/196184 | |
dc.description.abstract | Subcutaneous immunotherapy is the only treatment that improves the natural progression of allergic rhinitis and maintains long-term outcomes after discontinuation of the drug. Metabolomics is increasingly applied in the study of allergic diseases, including allergic rhinitis. However, little is known about the discovery of metabolites that can evaluate clinical efficacy and possible mechanisms of Artemisia sieversiana pollen subcutaneous immunotherapy. Thirty-three patients with Artemisia sieversiana pollen allergic rhinitis significantly improved after 1-year subcutaneous immunotherapy treatment, while ten patients were ineffective. Pre- and post-treatment serum samples from these patients were analyzed by metabolomics based on the combined detection of liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. As a result, L-Tyrosine can be a potential biomarker because of its opposite trend in effective patients and ineffective patients. And mechanism of immunotherapy may be closely related to NO and nitric oxide synthase. The discovery of potential biomarkers and metabolic pathways has contributed to the in-depth study of mechanisms of subcutaneous immunotherapy treatment of Artemisia sieversiana pollen allergic rhinitis. © Copyright © 2020 Shi, Pan, Ma, Chen, Yan, Liu, Cao, Huang, Wang, Wang and Wei. | |
dc.publisher | Frontiers Media S.A. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scopus OA2020 | |
dc.subject | clinical efficacy | |
dc.subject | GC-MS | |
dc.subject | LC-MS | |
dc.subject | metabolomics | |
dc.subject | seasonal allergic rhinitis | |
dc.subject | subcutaneous immunotherapy | |
dc.type | Article | |
dc.contributor.department | OTOLARYNGOLOGY | |
dc.description.doi | 10.3389/fphar.2020.00305 | |
dc.description.sourcetitle | Frontiers in Pharmacology | |
dc.description.volume | 11 | |
dc.description.page | 305 | |
Appears in Collections: | Elements Staff Publications |
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