DEVELOPMENT OF ROBUST AMPHIPHILIC COATING FOR DRUG COATED BALLOON

Abstract

The current most common form of revascularisation for coronary artery disease is the use of stent, through a procedure known as percutaneous coronary intervention (PCI). However, PCI is not limited to just the use of stents, as non-stent based approach such as DCBs and bioresorbable stents are beginning to gain traction due to their favourable long-term outcomes. These outcomes are centred on the premise of a ‘leave nothing behind’ approach when treating patients with CAD or PAD. Without implanting a permanent metallic stent within the vessel, the natural anatomy of the vessel is respected and vasomotion is maintained. Various clinical trials involving DCBs in treatment of de novo coronary lesions, in-stent restenosis and peripheral artery disease treatment haven shown some evidence of success. However, there is lack of a ‘class effect’ in the use of DCBs. Hence, this project aims to create an ideal amphiphilic excipient that can circumvent the shortcomings experienced by present day DCBs.