Please use this identifier to cite or link to this item: https://doi.org/10.1186/s43074-020-00009-7
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dc.titleCellular-resolution in vivo tomography in turbid tissue through digital aberration correction
dc.contributor.authorBo, En
dc.contributor.authorGe, Xin
dc.contributor.authorLuo, Yuemei
dc.contributor.authorWu, Xuan
dc.contributor.authorChen, Si
dc.contributor.authorLiang, Haitao
dc.contributor.authorChen, Shufen
dc.contributor.authorYu, Xiaojun
dc.contributor.authorShum, Ping
dc.contributor.authorMo, Jianhua
dc.contributor.authorChen, Nanguang
dc.contributor.authorLiu, Linbo
dc.date.accessioned2021-07-21T05:12:26Z
dc.date.available2021-07-21T05:12:26Z
dc.date.issued2020-12
dc.identifier.citationBo, En, Ge, Xin, Luo, Yuemei, Wu, Xuan, Chen, Si, Liang, Haitao, Chen, Shufen, Yu, Xiaojun, Shum, Ping, Mo, Jianhua, Chen, Nanguang, Liu, Linbo (2020-12). Cellular-resolution in vivo tomography in turbid tissue through digital aberration correction. PhotoniX 1 (1). ScholarBank@NUS Repository. https://doi.org/10.1186/s43074-020-00009-7
dc.identifier.issn26621991
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/194595
dc.description.abstractNoninvasive tomographic imaging of cellular processes in vivo may provide valuable cytological and histological information for disease diagnosis. However, such strategies are usually hampered by optical aberrations caused by the imaging system and tissue turbidity. State-of-the-art aberration correction methods require that the light signal be phase stable over the full-field data acquisition period, which is difficult to maintain during dynamic cellular processes in vivo. Here we show that any optical aberrations in the path length difference (OPD) domain can be corrected without the phase stability requirement based on maximum intensity assumption. Specifically, we demonstrate a novel optical tomographic technique, termed amplitude division aperture synthesis optical coherence tomography (ADAS-OCT), which corrects aberrations induced by turbid tissues by physical aperture synthesis and simultaneously data acquisition from sub-apertures. Even with just two subapertures, ADAS-OCT enabled in vivo visualization of red blood cells in human labial mucosa. We further demonstrated that adding sub-apertures could significantly scale up the aberration correction capability. This technology has the potential to impact a number of clinical areas where noninvasive examinations are preferred, such as blood count and cancers detection.
dc.publisherSpringer Science and Business Media LLC
dc.sourceElements
dc.subjectTurbid tissue
dc.subjectTomography
dc.subjectAberration correction
dc.subjectCellular resolution
dc.typeArticle
dc.date.updated2021-07-19T09:39:13Z
dc.contributor.departmentBIOMEDICAL ENGINEERING
dc.description.doi10.1186/s43074-020-00009-7
dc.description.sourcetitlePhotoniX
dc.description.volume1
dc.description.issue1
dc.published.statePublished
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