ROLE OF EPIGALLOCATECHIN-3-GALLATE IN THE BREAD DELIVERY SYSTEM ON LOWERING OBESITY RISK ON MICE MODEL

Abstract

Epigallocatechin gallate (EGCG) is the dominating green tea catechin with significant bioactivities on the metabolism regulation of lipids. However, the utilization of EGCG is limited by its poor bioavailability. Bread is an effective food delivery system, which could improve bio-functions of EGCG through synergistic interactions with the bread matrix. In this study, the anti-obesity function of EGCG-fortified bread was investigated.

The results revealed that the bread matrix had positive effects on the in vitro bioavailability of EGCG, regulation of lipids metabolism, gut microbiota, and obesity reduction based on the dietary intervention consequences of obese mice, indicating that bread delivery system for EGCG might be a promising approach to reduce obesity.