Please use this identifier to cite or link to this item:
https://doi.org/10.1002/ana.25967
DC Field | Value | |
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dc.title | The Impact of SARS-CoV-2 on Stroke Epidemiology and Care: A Meta-Analysis | |
dc.contributor.author | Katsanos, AH | |
dc.contributor.author | Palaiodimou, L | |
dc.contributor.author | Zand, R | |
dc.contributor.author | Yaghi, S | |
dc.contributor.author | Kamel, H | |
dc.contributor.author | Navi, BB | |
dc.contributor.author | Turc, G | |
dc.contributor.author | Romoli, M | |
dc.contributor.author | Sharma, VK | |
dc.contributor.author | Mavridis, D | |
dc.contributor.author | Shahjouei, S | |
dc.contributor.author | Catanese, L | |
dc.contributor.author | Shoamanesh, A | |
dc.contributor.author | Vadikolias, K | |
dc.contributor.author | Tsioufis, K | |
dc.contributor.author | Lagiou, P | |
dc.contributor.author | Alexandrov, AV | |
dc.contributor.author | Tsiodras, S | |
dc.contributor.author | Tsivgoulis, G | |
dc.date.accessioned | 2021-06-28T03:29:28Z | |
dc.date.available | 2021-06-28T03:29:28Z | |
dc.date.issued | 2021-02-01 | |
dc.identifier.citation | Katsanos, AH, Palaiodimou, L, Zand, R, Yaghi, S, Kamel, H, Navi, BB, Turc, G, Romoli, M, Sharma, VK, Mavridis, D, Shahjouei, S, Catanese, L, Shoamanesh, A, Vadikolias, K, Tsioufis, K, Lagiou, P, Alexandrov, AV, Tsiodras, S, Tsivgoulis, G (2021-02-01). The Impact of SARS-CoV-2 on Stroke Epidemiology and Care: A Meta-Analysis. Annals of Neurology 89 (2) : 380-388. ScholarBank@NUS Repository. https://doi.org/10.1002/ana.25967 | |
dc.identifier.issn | 03645134 | |
dc.identifier.issn | 15318249 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/192248 | |
dc.description.abstract | Objective: Emerging data indicate an increased risk of cerebrovascular events with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and highlight the potential impact of coronavirus disease (COVID-19) on the management and outcomes of acute stroke. We conducted a systematic review and meta-analysis to evaluate the aforementioned considerations. Methods: We performed a meta-analysis of observational cohort studies reporting on the occurrence and/or outcomes of patients with cerebrovascular events in association with their SARS-CoV-2 infection status. We used a random-effects model. Summary estimates were reported as odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Results: We identified 18 cohort studies including 67,845 patients. Among patients with SARS-CoV-2, 1.3% (95% CI = 0.9–1.6%, I2 = 87%) were hospitalized for cerebrovascular events, 1.1% (95% CI = 0.8–1.3%, I2 = 85%) for ischemic stroke, and 0.2% (95% CI = 0.1–0.3%, I2 = 64%) for hemorrhagic stroke. Compared to noninfected contemporary or historical controls, patients with SARS-CoV-2 infection had increased odds of ischemic stroke (OR = 3.58, 95% CI = 1.43–8.92, I2 = 43%) and cryptogenic stroke (OR = 3.98, 95% CI = 1.62–9.77, I2 = 0%). Diabetes mellitus was found to be more prevalent among SARS-CoV-2 stroke patients compared to noninfected historical controls (OR = 1.39, 95% CI = 1.00–1.94, I2 = 0%). SARS-CoV-2 infection status was not associated with the likelihood of receiving intravenous thrombolysis (OR = 1.42, 95% CI = 0.65–3.10, I2 = 0%) or endovascular thrombectomy (OR = 0.78, 95% CI = 0.35–1.74, I2 = 0%) among hospitalized ischemic stroke patients during the COVID-19 pandemic. Odds of in-hospital mortality were higher among SARS-CoV-2 stroke patients compared to noninfected contemporary or historical stroke patients (OR = 5.60, 95% CI = 3.19–9.80, I2 = 45%). Interpretation: SARS-CoV-2 appears to be associated with an increased risk of ischemic stroke, and potentially cryptogenic stroke in particular. It may also be related to an increased mortality risk. ANN NEUROL 2021;89:380–388. | |
dc.publisher | Wiley | |
dc.source | Elements | |
dc.subject | COVID-19 | |
dc.subject | Case-Control Studies | |
dc.subject | Comorbidity | |
dc.subject | Diabetes Mellitus | |
dc.subject | Hospital Mortality | |
dc.subject | Humans | |
dc.subject | SARS-CoV-2 | |
dc.subject | Stroke | |
dc.subject | Thrombectomy | |
dc.subject | Thrombolytic Therapy | |
dc.type | Article | |
dc.date.updated | 2021-06-25T15:29:12Z | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1002/ana.25967 | |
dc.description.sourcetitle | Annals of Neurology | |
dc.description.volume | 89 | |
dc.description.issue | 2 | |
dc.description.page | 380-388 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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The Impact of SARS-CoV-2 on Stroke Epidemiology and Care A Meta-Analysis.pdf | 1.21 MB | Adobe PDF | CLOSED | None |
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