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Title: | COOPERATIVITY IN CATALYSIS: CO-CATALYST ASSISTED PALLADIUM-CATALYZED TRANSFORMATIONS | Authors: | LEE JIN TU DANENCE | ORCID iD: | orcid.org/0000-0003-3156-9972 | Keywords: | Palladium, Copper, Cooperative, Catalysis, Alkynes, Enantioselective | Issue Date: | 23-Jan-2019 | Citation: | LEE JIN TU DANENCE (2019-01-23). COOPERATIVITY IN CATALYSIS: CO-CATALYST ASSISTED PALLADIUM-CATALYZED TRANSFORMATIONS. ScholarBank@NUS Repository. | Abstract: | This thesis describes our efforts in the development of novel co-catalyst assisted palladium-catalyzed transformations for the synthesis of valuable organic molecules. Drawing inspiration from a structurally interesting, bis-coordinating pyridazine ligand we synthesized, three separate discoveries were made. The first discovery involves an unprecedented copper(I) iodide assisted palladium-catalyzed trimerization of terminal alkynes. This reaction provides an operationally simple procedure to access acyclic Z-enediynes - a class of compound with proven anti-cancer properties. The second discovery involves a chiral amine assisted palladium-catalyzed α-allylation of unfunctionalized ketones. The enantioselective protocol described herein provides a direct method for the synthesis of valuable α-tertiary stereogenic centres. The thesis also describes the extensive screening of reaction parameters we undertook to realize this challenging organic transformation. Lastly, we present our preliminary findings on an f-block co-catalyst assisted palladium-catalyzed amination of primary alcohols via Borrowing-Hydrogen methodology. | URI: | https://scholarbank.nus.edu.sg/handle/10635/191709 |
Appears in Collections: | Ph.D Theses (Open) |
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