Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/191709
DC Field | Value | |
---|---|---|
dc.title | COOPERATIVITY IN CATALYSIS: CO-CATALYST ASSISTED PALLADIUM-CATALYZED TRANSFORMATIONS | |
dc.contributor.author | LEE JIN TU DANENCE | |
dc.date.accessioned | 2021-05-31T18:00:40Z | |
dc.date.available | 2021-05-31T18:00:40Z | |
dc.date.issued | 2019-01-23 | |
dc.identifier.citation | LEE JIN TU DANENCE (2019-01-23). COOPERATIVITY IN CATALYSIS: CO-CATALYST ASSISTED PALLADIUM-CATALYZED TRANSFORMATIONS. ScholarBank@NUS Repository. | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/191709 | |
dc.description.abstract | This thesis describes our efforts in the development of novel co-catalyst assisted palladium-catalyzed transformations for the synthesis of valuable organic molecules. Drawing inspiration from a structurally interesting, bis-coordinating pyridazine ligand we synthesized, three separate discoveries were made. The first discovery involves an unprecedented copper(I) iodide assisted palladium-catalyzed trimerization of terminal alkynes. This reaction provides an operationally simple procedure to access acyclic Z-enediynes - a class of compound with proven anti-cancer properties. The second discovery involves a chiral amine assisted palladium-catalyzed α-allylation of unfunctionalized ketones. The enantioselective protocol described herein provides a direct method for the synthesis of valuable α-tertiary stereogenic centres. The thesis also describes the extensive screening of reaction parameters we undertook to realize this challenging organic transformation. Lastly, we present our preliminary findings on an f-block co-catalyst assisted palladium-catalyzed amination of primary alcohols via Borrowing-Hydrogen methodology. | |
dc.language.iso | en | |
dc.subject | Palladium, Copper, Cooperative, Catalysis, Alkynes, Enantioselective | |
dc.type | Thesis | |
dc.contributor.department | CHEMISTRY | |
dc.contributor.supervisor | Yu Zhao | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY (FOS) | |
dc.identifier.orcid | 0000-0003-3156-9972 | |
Appears in Collections: | Ph.D Theses (Open) |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
LeeJTD.pdf | 5.66 MB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.