Please use this identifier to cite or link to this item:
https://doi.org/10.1212/WNL.0000000000000707
DC Field | Value | |
---|---|---|
dc.title | Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12 | |
dc.contributor.author | Kilarski, L.L | |
dc.contributor.author | Achterberg, S | |
dc.contributor.author | Devan, W.J | |
dc.date.accessioned | 2020-11-23T08:56:50Z | |
dc.date.available | 2020-11-23T08:56:50Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Kilarski, L.L, Achterberg, S, Devan, W.J (2014). Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology 83 (8) : 678-685. ScholarBank@NUS Repository. https://doi.org/10.1212/WNL.0000000000000707 | |
dc.identifier.issn | 0028-3878 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/183893 | |
dc.description.abstract | Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p 5 7.12 3 10-11) with ischemic stroke. The association was with all ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes. There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p 5 0.695).Conclusion: Our results show, for the first time, a genetic risk locus associated with ischemic stroke as a whole, rather than in a subtype-specific manner. This finding was not associated with intracerebral hemorrhage.Methods: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data from 3,548 cases and 5,972 controls recruited from the ischemic stroke WTCCC2 study, and with summary statistics from a further 8,480 cases and 56,032 controls in the METASTROKE consortium. A final in silico "look-up" of 2 single nucleotide polymorphisms in 2,522 cases and 1,899 controls was performed. Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls.Objectives: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases. © 2014 American Academy of Neurology. | |
dc.publisher | Lippincott, Williams & Wilkins | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | Article | |
dc.subject | brain hemorrhage | |
dc.subject | brain ischemia | |
dc.subject | cardioembolic stroke | |
dc.subject | cardiovascular risk | |
dc.subject | chromosome 10q | |
dc.subject | chromosome 12q | |
dc.subject | chromosome 7p | |
dc.subject | computer model | |
dc.subject | controlled study | |
dc.subject | coronary artery disease | |
dc.subject | diabetes mellitus | |
dc.subject | genetic association | |
dc.subject | genotype | |
dc.subject | human | |
dc.subject | hypercholesterolemia | |
dc.subject | hypertension | |
dc.subject | immunochip array | |
dc.subject | major clinical study | |
dc.subject | microarray analysis | |
dc.subject | risk factor | |
dc.subject | single nucleotide polymorphism | |
dc.subject | brain ischemia | |
dc.subject | chromosome 12 | |
dc.subject | genetic association | |
dc.subject | genetic predisposition | |
dc.subject | genetics | |
dc.subject | meta analysis | |
dc.subject | risk | |
dc.subject | Stroke | |
dc.subject | Brain Ischemia | |
dc.subject | Cerebral Hemorrhage | |
dc.subject | Chromosomes, Human, Pair 12 | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genotype | |
dc.subject | Humans | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Risk | |
dc.subject | Stroke | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1212/WNL.0000000000000707 | |
dc.description.sourcetitle | Neurology | |
dc.description.volume | 83 | |
dc.description.issue | 8 | |
dc.description.page | 678-685 | |
dc.published.state | published | |
Appears in Collections: | Staff Publications Elements |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1212_WNL_0000000000000707.pdf | 434.79 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License