Please use this identifier to cite or link to this item: https://doi.org/10.1155/2016/4680972
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dc.titleAbnormal resting-state functional connectivity strength in mild cognitive impairment and its conversion to Alzheimer's disease
dc.contributor.authorLi, Y
dc.contributor.authorWang, X
dc.contributor.authorLi, Y
dc.contributor.authorSun, Y
dc.contributor.authorSheng, C
dc.contributor.authorLi, H
dc.contributor.authorLi, X
dc.contributor.authorYu, Y
dc.contributor.authorChen, G
dc.contributor.authorHu, X
dc.contributor.authorJing, B
dc.contributor.authorWang, D
dc.contributor.authorLi, K
dc.contributor.authorJessen, F
dc.contributor.authorXia, M
dc.contributor.authorHan, Y
dc.date.accessioned2020-11-19T09:39:58Z
dc.date.available2020-11-19T09:39:58Z
dc.date.issued2016
dc.identifier.citationLi, Y, Wang, X, Li, Y, Sun, Y, Sheng, C, Li, H, Li, X, Yu, Y, Chen, G, Hu, X, Jing, B, Wang, D, Li, K, Jessen, F, Xia, M, Han, Y (2016). Abnormal resting-state functional connectivity strength in mild cognitive impairment and its conversion to Alzheimer's disease. Neural Plasticity 2016 : 4680972. ScholarBank@NUS Repository. https://doi.org/10.1155/2016/4680972
dc.identifier.issn20905904
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183728
dc.description.abstractIndividuals diagnosed with mild cognitive impairment (MCI) are at high risk of transition to Alzheimer's disease (AD). However, little is known about functional characteristics of the conversion from MCI to AD. Resting-state functional magnetic resonance imaging was performed in 25 AD patients, 31 MCI patients, and 42 well-matched normal controls at baseline. Twenty-one of the 31 MCI patients converted to AD at approximately 24 months of follow-up. Functional connectivity strength (FCS) and seed-based functional connectivity analyses were used to assess the functional differences among the groups. Compared to controls, subjects with MCI and AD showed decreased FCS in the default-mode network and the occipital cortex. Importantly, the FCS of the left angular gyrus and middle occipital gyrus was significantly lower in MCI-converters as compared with MCI-nonconverters. Significantly decreased functional connectivity was found in MCI-converters compared to nonconverters between the left angular gyrus and bilateral inferior parietal lobules, dorsolateral prefrontal and lateral temporal cortices, and the left middle occipital gyrus and right middle occipital gyri. We demonstrated gradual but progressive functional changes during a median 2-year interval in patients converting from MCI to AD, which might serve as early indicators for the dysfunction and progression in the early stage of AD. @ 2016 Yuxia Li et al.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectadult
dc.subjectaged
dc.subjectAlzheimer disease
dc.subjectangular gyrus
dc.subjectArticle
dc.subjectclock drawing test
dc.subjectconnectome
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdefault mode network
dc.subjectdisease course
dc.subjectdorsolateral prefrontal cortex
dc.subjectfemale
dc.subjectfunctional connectivity strength
dc.subjectfunctional magnetic resonance imaging
dc.subjecthuman
dc.subjectinferior parietal lobule
dc.subjectleft hemisphere
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle occipital gyrus
dc.subjectmild cognitive impairment
dc.subjectMini Mental State Examination
dc.subjectMontreal cognitive assessment
dc.subjectnuclear magnetic resonance scanner
dc.subjectresting state network
dc.subjectRey auditory verbal learning test
dc.subjectright hemisphere
dc.subjectsupport vector machine
dc.subjecttemporal cortex
dc.subjectAlzheimer disease
dc.subjectbrain
dc.subjectbrain mapping
dc.subjectcognitive defect
dc.subjectmiddle aged
dc.subjectnerve cell network
dc.subjectnuclear magnetic resonance imaging
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAlzheimer Disease
dc.subjectBrain
dc.subjectBrain Mapping
dc.subjectCognitive Dysfunction
dc.subjectConnectome
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNerve Net
dc.typeArticle
dc.contributor.departmentLIFE SCIENCES INSTITUTE
dc.description.doi10.1155/2016/4680972
dc.description.sourcetitleNeural Plasticity
dc.description.volume2016
dc.description.page4680972
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