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Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms17060940
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dc.titleHepatitis B virus X protein and hepatocarcinogenesis
dc.contributor.authorLiu, S
dc.contributor.authorKoh, S.S.Y
dc.contributor.authorLee, C.G.L
dc.date.accessioned2020-11-10T07:55:56Z
dc.date.available2020-11-10T07:55:56Z
dc.date.issued2016
dc.identifier.citationLiu, S, Koh, S.S.Y, Lee, C.G.L (2016). Hepatitis B virus X protein and hepatocarcinogenesis. International Journal of Molecular Sciences 17 (6) : 940. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms17060940
dc.identifier.issn16616596
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183327
dc.description.abstractChronic hepatitis B virus (HBV) infection is one of the most associated factors in hepatocarcinogenesis. HBV is able to integrate into the host genome and encode the multi-functional hepatitis B virus x protein (HBx). Although the mechanism between HBx and carcinogenesis is still elusive, recent studies have shown that HBx was able to influence various signaling pathways, as well as epigenetic and genetic processes. This review will examine and summarize recent literature about HBx’s role in these various processes. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectalpha fetoprotein
dc.subjectchemokine receptor CXCR4
dc.subjecthepatitis B virus X protein
dc.subjectlong untranslated RNA
dc.subjectmammalian target of rapamycin
dc.subjectmicroRNA
dc.subjectNotch receptor
dc.subjectphosphatidylinositol 3 kinase
dc.subjectphosphatidylinositol 3,4,5 trisphosphate 3 phosphatase
dc.subjectprotein bcl 2
dc.subjectRas protein
dc.subjectreactive oxygen metabolite
dc.subjectsecreted frizzled related protein 1
dc.subjectsecreted frizzled related protein 5
dc.subjectsomatomedin B
dc.subjectsomatomedin binding protein 3
dc.subjecttoll like receptor 3
dc.subjecttumor necrosis factor related apoptosis inducing ligand
dc.subjectuntranslated RNA
dc.subjecthepatitis B virus X protein
dc.subjecttransactivator protein
dc.subjectacetylation
dc.subjectapoptosis
dc.subjectchronic hepatitis B
dc.subjectDNA methylation
dc.subjectDNA repair
dc.subjectepigenetics
dc.subjectgene expression
dc.subjectgene mutation
dc.subjecthuman
dc.subjectimmunity
dc.subjectliver cell carcinoma
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectprotein expression
dc.subjectReview
dc.subjectsignal transduction
dc.subjectanimal
dc.subjectgenetic epigenesis
dc.subjectgenetics
dc.subjectliver cell carcinoma
dc.subjectliver tumor
dc.subjectmetabolism
dc.subjectvirology
dc.subjectAnimals
dc.subjectCarcinoma, Hepatocellular
dc.subjectEpigenesis, Genetic
dc.subjectHumans
dc.subjectLiver Neoplasms
dc.subjectSignal Transduction
dc.subjectTrans-Activators
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.3390/ijms17060940
dc.description.sourcetitleInternational Journal of Molecular Sciences
dc.description.volume17
dc.description.issue6
dc.description.page940
dc.published.statePublished
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