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https://doi.org/10.1186/1471-244X-11-76
Title: | Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder | Authors: | Morey, R.A Hariri, A.R Gold, A.L Hauser, M.A Munger, H.J Dolcos, F McCarthy, G |
Keywords: | citalopram escitalopram fluoxetine fluvoxamine mirtazapine paroxetine serotonin transporter sertraline serotonin transporter SLC6A4 protein, human adult allele amygdaloid nucleus article brain function brain region clinical article cognition controlled study emotion emotional disorder executive function exon female functional magnetic resonance imaging fusiform gyrus gene expression gene structure genetic variability genotype human intron male memory consolidation nerve cell phenotype posttraumatic stress disorder promoter region race response time signal transduction single nucleotide polymorphism task performance veteran visual information working memory case control study cognition emotion functional neuroimaging genetics injury methodology nuclear magnetic resonance imaging pathophysiology physiology posttraumatic stress disorder prefrontal cortex psychological aspect psychomotor performance short term memory terrorism Amygdala Case-Control Studies Cognition Emotions Functional Neuroimaging Humans Magnetic Resonance Imaging Memory, Short-Term Polymorphism, Single Nucleotide Prefrontal Cortex Promoter Regions, Genetic Psychomotor Performance September 11 Terrorist Attacks Serotonin Plasma Membrane Transport Proteins Stress Disorders, Post-Traumatic Veterans Wounds and Injuries |
Issue Date: | 2011 | Citation: | Morey, R.A, Hariri, A.R, Gold, A.L, Hauser, M.A, Munger, H.J, Dolcos, F, McCarthy, G (2011). Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder. BMC Psychiatry 11 : 76. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-244X-11-76 | Rights: | Attribution 4.0 International | Abstract: | Background: Serotonergic system dysfunction has been implicated in posttraumatic stress disorder (PTSD). Genetic polymorphisms associated with serotonin signaling may predict differences in brain circuitry involved in emotion processing and deficits associated with PTSD. In healthy individuals, common functional polymorphisms in the serotonin transporter gene (SLC6A4) have been shown to modulate amygdala and prefrontal cortex (PFC) activity in response to salient emotional stimuli. Similar patterns of differential neural responses to emotional stimuli have been demonstrated in PTSD but genetic factors influencing these activations have yet to be examined.Methods: We investigated whether SLC6A4 promoter polymorphisms (5-HTTLPR, rs25531) and several downstream single nucleotide polymorphisms (SNPs) modulated activity of brain regions involved in the cognitive control of emotion in post-9/11 veterans with PTSD. We used functional MRI to examine neural activity in a PTSD group (n = 22) and a trauma-exposed control group (n = 20) in response to trauma-related images presented as task-irrelevant distractors during the active maintenance period of a delayed-response working memory task. Regions of interest were derived by contrasting activation for the most distracting and least distracting conditions across participants.Results: In patients with PTSD, when compared to trauma-exposed controls, rs16965628 (associated with serotonin transporter gene expression) modulated task-related ventrolateral PFC activation and 5-HTTLPR tended to modulate left amygdala activation. Subsequent to combat-related trauma, these SLC6A4 polymorphisms may bias serotonin signaling and the neural circuitry mediating cognitive control of emotion in patients with PTSD.Conclusions: The SLC6A4 SNP rs16965628 and 5-HTTLPR are associated with a bias in neural responses to traumatic reminders and cognitive control of emotions in patients with PTSD. Functional MRI may help identify intermediate phenotypes and dimensions of PTSD that clarify the functional link between genes and disease phenotype, and also highlight features of PTSD that show more proximal influence of susceptibility genes compared to current clinical categorizations. © 2011 Morey et al; licensee BioMed Central Ltd. | Source Title: | BMC Psychiatry | URI: | https://scholarbank.nus.edu.sg/handle/10635/181637 | ISSN: | 1471244X | DOI: | 10.1186/1471-244X-11-76 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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