Please use this identifier to cite or link to this item:
https://doi.org/10.1186/1471-230X-14-156
DC Field | Value | |
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dc.title | Factors influencing treatment outcome in patients with gastroesophageal reflux disease: Outcome of a prospective pragmatic trial in Asian patients | |
dc.contributor.author | Goh, K.L | |
dc.contributor.author | Choi, K.D | |
dc.contributor.author | Choi, M.-G | |
dc.contributor.author | Hsieh, T.-Y | |
dc.contributor.author | Jung, H.-Y | |
dc.contributor.author | Lien, H.-C | |
dc.contributor.author | Menon, J | |
dc.contributor.author | Mesenas, S | |
dc.contributor.author | Park, H | |
dc.contributor.author | Sheu, B.-S | |
dc.contributor.author | Wu, J.C.Y | |
dc.date.accessioned | 2020-10-27T11:05:08Z | |
dc.date.available | 2020-10-27T11:05:08Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Goh, K.L, Choi, K.D, Choi, M.-G, Hsieh, T.-Y, Jung, H.-Y, Lien, H.-C, Menon, J, Mesenas, S, Park, H, Sheu, B.-S, Wu, J.C.Y (2014). Factors influencing treatment outcome in patients with gastroesophageal reflux disease: Outcome of a prospective pragmatic trial in Asian patients. BMC Gastroenterology 14 (1) : 156. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-230X-14-156 | |
dc.identifier.issn | 1471230X | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/181487 | |
dc.description.abstract | Background: Predicting response to proton pump inhibitor (PPI) treatment can aid the effective management of gastroesophageal reflux disease (GERD). The aim was to investigate the predictors of symptomatic response to pantoprazole in Asian patients with GERD; the first study of its kind in Asian patients. Methods: Asian patients with GERD symptoms (N = 209) received pantoprazole 40 mg daily for 8 weeks in a multinational, prospective, open-label study. Response was assessed using ReQuest™. Baseline and demographic factors were examined using logistic regression to determine if they were related to treatment response. Results: Response rates were 44.3% (Week 4) and 63.6% (Week 8) in Asian patients versus 60.7% (P < 0.001) and 72.2% (P = 0.010) for the rest of the world. Higher response rates at 8 weeks occurred in patients with erosive reflux disease (ERD; 71.3%) versus those with non-erosive reflux disease (NERD) at baseline (48.5%). The presence of ERD (P = 0.0143) and lower ReQuest™-GI scores at baseline (P = 0.0222) were associated with response. Improvements in quality of life (QoL) and anxiety and depression at 4 and 8 weeks were associated with treatment response (both P < 0.0001). Patient satisfaction correlated with treatment response (P < 0.0001), and improvement in anxiety and depression (P < 0.0001) and QoL (P < 0.0001). Conclusions: Asian patients with GERD, especially those with NERD, may have lower response rates to PPIs than Western populations. ERD and less severe gastrointestinal symptoms may help to predict symptomatic responses to PPIs in Asian patients. Trial Registration: ClinicalTrial.gov identifier: NCT00312806. © 2014 Goh et al.; licensee BioMed Central Ltd. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | pantoprazole | |
dc.subject | 2 [[(2 pyridyl)methyl]sulfinyl]benzimidazole derivative | |
dc.subject | pantoprazole | |
dc.subject | proton pump inhibitor | |
dc.subject | abdominal pain | |
dc.subject | adult | |
dc.subject | anxiety | |
dc.subject | Article | |
dc.subject | Asian | |
dc.subject | clinical trial | |
dc.subject | constipation | |
dc.subject | depression | |
dc.subject | diarrhea | |
dc.subject | disease severity | |
dc.subject | drug efficacy | |
dc.subject | drug fatality | |
dc.subject | drug safety | |
dc.subject | ethnic difference | |
dc.subject | female | |
dc.subject | gastroesophageal reflux | |
dc.subject | gastrointestinal symptom | |
dc.subject | headache | |
dc.subject | heart arrhythmia | |
dc.subject | Hong Kong | |
dc.subject | human | |
dc.subject | influenza | |
dc.subject | insomnia | |
dc.subject | Korea | |
dc.subject | major clinical study | |
dc.subject | Malaysia | |
dc.subject | male | |
dc.subject | morning dosage | |
dc.subject | multicenter study | |
dc.subject | non erosive reflux disease | |
dc.subject | open study | |
dc.subject | outcome assessment | |
dc.subject | patient satisfaction | |
dc.subject | prospective study | |
dc.subject | quality of life | |
dc.subject | reflux esophagitis | |
dc.subject | rhinopharyngitis | |
dc.subject | Singapore | |
dc.subject | Taiwan | |
dc.subject | treatment duration | |
dc.subject | treatment outcome | |
dc.subject | treatment response | |
dc.subject | upper respiratory tract infection | |
dc.subject | vomiting | |
dc.subject | Asian continental ancestry group | |
dc.subject | gastroesophageal reflux | |
dc.subject | middle aged | |
dc.subject | psychology | |
dc.subject | questionnaire | |
dc.subject | 2-Pyridinylmethylsulfinylbenzimidazoles | |
dc.subject | Adult | |
dc.subject | Anxiety | |
dc.subject | Asian Continental Ancestry Group | |
dc.subject | Depression | |
dc.subject | Female | |
dc.subject | Gastroesophageal Reflux | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Patient Satisfaction | |
dc.subject | Prospective Studies | |
dc.subject | Proton Pump Inhibitors | |
dc.subject | Quality of Life | |
dc.subject | Questionnaires | |
dc.subject | Treatment Outcome | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1186/1471-230X-14-156 | |
dc.description.sourcetitle | BMC Gastroenterology | |
dc.description.volume | 14 | |
dc.description.issue | 1 | |
dc.description.page | 156 | |
Appears in Collections: | Elements Staff Publications |
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