Please use this identifier to cite or link to this item: https://doi.org/10.1128/CVI.00452-15
Title: Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort
Authors: Dent, A.E
Malhotra, I
Wang, X
Babineau, D
Yeo, K.T 
Anderson, T
Kimmel, R.J
Angov, E
Lanar, D.E
Narum, D
Dutta, S
Richards, J
Beeson, J.G
Crabb, B.S
Cowman, A.F
Horii, T
Muchiri, E
Mungai, P.L
King, C.L
Kazura, J.W
Keywords: biological marker
immunoglobulin G
immunoglobulin M
merozoite surface protein 1
parasite antigen
protozoal protein
protozoon antibody
age
blood
female
fetus blood
growth, development and aging
human
immunology
infant
Kenya
Malaria, Falciparum
male
newborn
passive immunization
Plasmodium falciparum
pregnancy
Pregnancy Complications, Parasitic
preschool child
serology
Age Factors
Antibodies, Protozoan
Antigens, Protozoan
Biomarkers
Child, Preschool
Female
Fetal Blood
Humans
Immunity, Maternally-Acquired
Immunoglobulin G
Immunoglobulin M
Infant
Infant, Newborn
Kenya
Malaria, Falciparum
Male
Merozoite Surface Protein 1
Plasmodium falciparum
Pregnancy
Pregnancy Complications, Parasitic
Protozoan Proteins
Serologic Tests
Issue Date: 2016
Citation: Dent, A.E, Malhotra, I, Wang, X, Babineau, D, Yeo, K.T, Anderson, T, Kimmel, R.J, Angov, E, Lanar, D.E, Narum, D, Dutta, S, Richards, J, Beeson, J.G, Crabb, B.S, Cowman, A.F, Horii, T, Muchiri, E, Mungai, P.L, King, C.L, Kazura, J.W (2016). Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort. Clinical and Vaccine Immunology 23 (2) : 104-116. ScholarBank@NUS Repository. https://doi.org/10.1128/CVI.00452-15
Rights: Attribution 4.0 International
Abstract: IgG antibodies to Plasmodium falciparum are transferred from the maternal to fetal circulation during pregnancy, wane after birth, and are subsequently acquired in response to natural infection. We examined the dynamics of malaria antibody responses of 84 Kenyan infants from birth to 36 months of age by (i) serology, (ii) variant surface antigen (VSA) assay, (iii) growth inhibitory activity (GIA), and (iv) invasion inhibition assays (IIA) specific for merozoite surface protein 1 (MSP1) and sialic acid-dependent invasion pathway. Maternal antibodies in each of these four categories were detected in cord blood and decreased to their lowest level by approximately 6 months of age. Serologic antibodies to 3 preerythrocytic and 10 blood-stage antigens subsequently increased, reaching peak prevalence by 36 months. In contrast, antibodies measured by VSA, GIA, and IIA remained low even up to 36 months. Infants sensitized to P. falciparum in utero, defined by cord blood lymphocyte recall responses to malaria antigens, acquired antimalarial antibodies at the same rate as those who were not sensitized in utero, indicating that fetal exposure to malaria antigens did not affect subsequent infant antimalarial responses. Infants with detectable serologic antibodies at 12 months of age had an increased risk of P. falciparum infection during the subsequent 24 months. We conclude that serologic measures of antimalarial antibodies in children 36 months of age or younger represent biomarkers of malaria exposure rather than protection and that functional antibodies develop after 36 months of age in this population. Copyright © 2016 American Society for Microbiology. All Rights Reserved.
Source Title: Clinical and Vaccine Immunology
URI: https://scholarbank.nus.edu.sg/handle/10635/181392
ISSN: 15566811
DOI: 10.1128/CVI.00452-15
Rights: Attribution 4.0 International
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