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https://doi.org/10.1128/CVI.00452-15
Title: | Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort | Authors: | Dent, A.E Malhotra, I Wang, X Babineau, D Yeo, K.T Anderson, T Kimmel, R.J Angov, E Lanar, D.E Narum, D Dutta, S Richards, J Beeson, J.G Crabb, B.S Cowman, A.F Horii, T Muchiri, E Mungai, P.L King, C.L Kazura, J.W |
Keywords: | biological marker immunoglobulin G immunoglobulin M merozoite surface protein 1 parasite antigen protozoal protein protozoon antibody age blood female fetus blood growth, development and aging human immunology infant Kenya Malaria, Falciparum male newborn passive immunization Plasmodium falciparum pregnancy Pregnancy Complications, Parasitic preschool child serology Age Factors Antibodies, Protozoan Antigens, Protozoan Biomarkers Child, Preschool Female Fetal Blood Humans Immunity, Maternally-Acquired Immunoglobulin G Immunoglobulin M Infant Infant, Newborn Kenya Malaria, Falciparum Male Merozoite Surface Protein 1 Plasmodium falciparum Pregnancy Pregnancy Complications, Parasitic Protozoan Proteins Serologic Tests |
Issue Date: | 2016 | Citation: | Dent, A.E, Malhotra, I, Wang, X, Babineau, D, Yeo, K.T, Anderson, T, Kimmel, R.J, Angov, E, Lanar, D.E, Narum, D, Dutta, S, Richards, J, Beeson, J.G, Crabb, B.S, Cowman, A.F, Horii, T, Muchiri, E, Mungai, P.L, King, C.L, Kazura, J.W (2016). Contrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort. Clinical and Vaccine Immunology 23 (2) : 104-116. ScholarBank@NUS Repository. https://doi.org/10.1128/CVI.00452-15 | Rights: | Attribution 4.0 International | Abstract: | IgG antibodies to Plasmodium falciparum are transferred from the maternal to fetal circulation during pregnancy, wane after birth, and are subsequently acquired in response to natural infection. We examined the dynamics of malaria antibody responses of 84 Kenyan infants from birth to 36 months of age by (i) serology, (ii) variant surface antigen (VSA) assay, (iii) growth inhibitory activity (GIA), and (iv) invasion inhibition assays (IIA) specific for merozoite surface protein 1 (MSP1) and sialic acid-dependent invasion pathway. Maternal antibodies in each of these four categories were detected in cord blood and decreased to their lowest level by approximately 6 months of age. Serologic antibodies to 3 preerythrocytic and 10 blood-stage antigens subsequently increased, reaching peak prevalence by 36 months. In contrast, antibodies measured by VSA, GIA, and IIA remained low even up to 36 months. Infants sensitized to P. falciparum in utero, defined by cord blood lymphocyte recall responses to malaria antigens, acquired antimalarial antibodies at the same rate as those who were not sensitized in utero, indicating that fetal exposure to malaria antigens did not affect subsequent infant antimalarial responses. Infants with detectable serologic antibodies at 12 months of age had an increased risk of P. falciparum infection during the subsequent 24 months. We conclude that serologic measures of antimalarial antibodies in children 36 months of age or younger represent biomarkers of malaria exposure rather than protection and that functional antibodies develop after 36 months of age in this population. Copyright © 2016 American Society for Microbiology. All Rights Reserved. | Source Title: | Clinical and Vaccine Immunology | URI: | https://scholarbank.nus.edu.sg/handle/10635/181392 | ISSN: | 15566811 | DOI: | 10.1128/CVI.00452-15 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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