Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s12933-016-0387-4
Title: | The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: The Rotterdam study | Authors: | Herpt, T.T.W Dehghan, A Hoek, M Ikram, M.A Hofman, A Sijbrands, E.J.G Franco, O.H |
Keywords: | glucose high density lipoprotein cholesterol triacylglycerol adult Article cardiometabolic risk cardiovascular mortality cerebrovascular accident cholesterol blood level clinical practice cohort analysis controlled study diastolic blood pressure female high risk patient human incidence ischemic heart disease major clinical study male metabolic syndrome X mortality Netherlands non insulin dependent diabetes mellitus predictive value prevalence prospective study systolic blood pressure triacylglycerol blood level aged Caucasian complication Coronary Disease Diabetes Mellitus, Type 2 insulin resistance metabolic syndrome X middle aged physiology risk factor United States Aged Coronary Disease Diabetes Mellitus, Type 2 European Continental Ancestry Group Female Humans Insulin Resistance Male Metabolic Syndrome X Middle Aged Prevalence Prospective Studies Risk Factors United States |
Issue Date: | 2016 | Citation: | Herpt, T.T.W, Dehghan, A, Hoek, M, Ikram, M.A, Hofman, A, Sijbrands, E.J.G, Franco, O.H (2016). The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: The Rotterdam study. Cardiovascular Diabetology 15 (1) : 69. ScholarBank@NUS Repository. https://doi.org/10.1186/s12933-016-0387-4 | Rights: | Attribution 4.0 International | Abstract: | Background: To evaluate the clinical value of metabolic syndrome based on different definitions [American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI), International Diabetes Federation (IDF) and European Group for the Study of Insulin Resistance (EGIR)] in middle-aged and elderly populations. Methods: We studied 8643 participants from the Rotterdam study (1990-2012; mean age 62.7; 57.6% female), a large prospective population-based study with predominantly elderly participants. We performed cox-proportional hazards models for different definitions, triads within definitions and each separate component for the risk of incident type 2 diabetes mellitus, coronary heart disease, stroke, cardiovascular- and all-cause mortality. Results: In our population of 8643 subjects, metabolic syndrome was highly prevalent (prevalence between 19.4 and 42.4%). Metabolic syndrome in general was associated with incident type 2 diabetes mellitus (median follow-up of 6.8years, hazard ratios 3.13-3.78). The associations with coronary heart disease (median follow-up of 7.2years, hazard ratios 1.08-1.32), stroke (median follow-up of 7.7years, hazard ratios 0.98-1.32), cardiovascular mortality (median follow-up of 8.2years, ratios 0.95-1.29) and all-cause mortality (median follow-up of 8.7years, hazard ratios 1.05-1.10) were weaker. AHA/NHLBI- and IDF-definitions showed similar associations with clinical endpoints compared to the EGIR, which was only significantly associated with incident type 2 diabetes mellitus. All significant associations disappeared after correcting metabolic syndrome for its individual components. Conclusions: Large variability exists between and within definitions of the metabolic syndrome with respect to risk of clinical events and mortality. In a relatively old population the metabolic syndrome did not show an additional predictive value on top of its individual components. So, besides as a manner of easy identification of high risk patients, the metabolic syndrome does not seem to add any predictive value for clinical practice. © 2016 van Herpt et al. | Source Title: | Cardiovascular Diabetology | URI: | https://scholarbank.nus.edu.sg/handle/10635/181373 | ISSN: | 14752840 | DOI: | 10.1186/s12933-016-0387-4 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1186_s12933-016-0387-4.pdf | 816.48 kB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License