Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s12957-016-1033-z
DC Field | Value | |
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dc.title | The expression of metastasis-associated in colon cancer-1 and KAI1 in gastric adenocarcinoma and their clinical significance | |
dc.contributor.author | Lu, G | |
dc.contributor.author | Zhou, L | |
dc.contributor.author | Zhang, X | |
dc.contributor.author | Zhu, B | |
dc.contributor.author | Wu, S | |
dc.contributor.author | Song, W | |
dc.contributor.author | Gong, X | |
dc.contributor.author | Wang, D | |
dc.contributor.author | Tao, Y | |
dc.date.accessioned | 2020-10-27T10:35:44Z | |
dc.date.available | 2020-10-27T10:35:44Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Lu, G, Zhou, L, Zhang, X, Zhu, B, Wu, S, Song, W, Gong, X, Wang, D, Tao, Y (2016). The expression of metastasis-associated in colon cancer-1 and KAI1 in gastric adenocarcinoma and their clinical significance. World Journal of Surgical Oncology 14 (1) : 276. ScholarBank@NUS Repository. https://doi.org/10.1186/s12957-016-1033-z | |
dc.identifier.issn | 14777819 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/181330 | |
dc.description.abstract | Background: The most common reason for malignant tumor treatment failure is recurrence and metastasis. Metastasis-associated in colon cancer-1 (MACC1) was originally identified as a metastatic and prognostic biomarker for colon cancer and later other solid tumors. Kangai 1 (KAI1), a marker of suppressor of metastasis, is also associated with metastasis and poor prognosis in many tumors. However, the prognostic value of either MACC1 or KAI1 in gastric adenocarcinoma (GAC) is unclear. In this study, we explored the relationship between MACC1 and KAI1 expression, as well as their respective correlation with clinicopathological features, to determine if either could be helpful for improvement of survival prognosis in GAC patients. Methods: The expression levels of both MACC1 and KAI1 in 325 whole-tissue sections of GAC were examined by immunohistochemistry. Clinical data was also collected. Results: MACC1 was significantly overexpressed in GAC tissues when compared to levels in normal gastric tissues; KAI1 was significantly down-expressed in GAC tissues when compared to levels in normal gastric tissues. Investigation of association between MACC1 and KAI1 protein levels with clinicopathological parameters of GAC indicated association between the expression of each with tumor grade, lymph node metastasis, invasive depth, and TNM stages. The overall survival time of patients with MACC1- or KAI1-positive GAC tumors was significantly shorter or longer than that of those who were negative. Importantly, multivariate analysis suggested that positive expression of either MACC1 or KAI1, as well as TNM stage, could be independent prognostic factors for overall survival in patients with GAC. Conclusions: MACC1 and KAI1 may represent promising metastatic and prognostic biomarkers, as well as potential therapeutic targets, for GAC. © 2016 The Author(s). | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | Kangai 1 | |
dc.subject | metastasis associated in colon cancer 1 protein | |
dc.subject | tumor protein | |
dc.subject | unclassified drug | |
dc.subject | CD82 antigen | |
dc.subject | CD82 protein, human | |
dc.subject | MACC1 protein, human | |
dc.subject | transcription factor | |
dc.subject | tumor marker | |
dc.subject | adult | |
dc.subject | Article | |
dc.subject | cancer grading | |
dc.subject | cancer patient | |
dc.subject | cancer prognosis | |
dc.subject | cancer staging | |
dc.subject | cancer survival | |
dc.subject | colon cancer | |
dc.subject | controlled study | |
dc.subject | female | |
dc.subject | histopathology | |
dc.subject | human | |
dc.subject | human tissue | |
dc.subject | immunohistochemistry | |
dc.subject | lymph node metastasis | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | overall survival | |
dc.subject | protein expression | |
dc.subject | protein function | |
dc.subject | stomach adenocarcinoma | |
dc.subject | survival time | |
dc.subject | tumor biopsy | |
dc.subject | tumor volume | |
dc.subject | adenocarcinoma | |
dc.subject | aged | |
dc.subject | case control study | |
dc.subject | enzyme immunoassay | |
dc.subject | follow up | |
dc.subject | gene expression regulation | |
dc.subject | lymph node metastasis | |
dc.subject | metabolism | |
dc.subject | middle aged | |
dc.subject | pathology | |
dc.subject | prognosis | |
dc.subject | secondary | |
dc.subject | stomach tumor | |
dc.subject | survival rate | |
dc.subject | tumor invasion | |
dc.subject | Adenocarcinoma | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Antigens, CD82 | |
dc.subject | Biomarkers, Tumor | |
dc.subject | Case-Control Studies | |
dc.subject | Female | |
dc.subject | Follow-Up Studies | |
dc.subject | Gene Expression Regulation, Neoplastic | |
dc.subject | Humans | |
dc.subject | Immunoenzyme Techniques | |
dc.subject | Lymphatic Metastasis | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Neoplasm Grading | |
dc.subject | Neoplasm Invasiveness | |
dc.subject | Neoplasm Staging | |
dc.subject | Prognosis | |
dc.subject | Stomach Neoplasms | |
dc.subject | Survival Rate | |
dc.subject | Transcription Factors | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1186/s12957-016-1033-z | |
dc.description.sourcetitle | World Journal of Surgical Oncology | |
dc.description.volume | 14 | |
dc.description.issue | 1 | |
dc.description.page | 276 | |
Appears in Collections: | Elements Staff Publications |
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