Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.6723
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dc.titleCD147 regulates cancer migration via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling
dc.contributor.authorCui, H.-Y
dc.contributor.authorWang, S.-J
dc.contributor.authorMiao, J.-Y
dc.contributor.authorFu, Z.-G
dc.contributor.authorFeng, F
dc.contributor.authorWu, J
dc.contributor.authorYang, X.-M
dc.contributor.authorChen, Z.-N
dc.contributor.authorJiang, J.-L
dc.date.accessioned2020-10-27T05:30:02Z
dc.date.available2020-10-27T05:30:02Z
dc.date.issued2016
dc.identifier.citationCui, H.-Y, Wang, S.-J, Miao, J.-Y, Fu, Z.-G, Feng, F, Wu, J, Yang, X.-M, Chen, Z.-N, Jiang, J.-L (2016). CD147 regulates cancer migration via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling. Oncotarget 7 (5) : 5613-5629. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.6723
dc.identifier.issn19492553
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/180863
dc.description.abstractThe acquisition of inappropriate migratory feature is crucial for tumor metastasis. It has been suggested that CD147 and Annexin A2 are involved in regulating tumor cell movement, while the regulatory mechanisms are far from clear. In this study, we demonstrated that CD147 physically interacted with the N-terminal domain of Annexin A2 and decreased Annexin A2 phosphorylation on tyrosine 23. In vitro kinase assay showed that the I domain of CD147 was indispensable for CD147-mediated downregulation of Annexin A2 phosphorylation by Src. Furthermore, we determined that p-Annexin A2 promoted the expression of dedicator of cytokinesis 3 (DOCK3) and DOCK3 blocked β-catenin nuclear translocation, resulting in inhibition of β-catenin signaling. In addition, DOCK3 inhibited lamellipodium dynamics and tumor cell movement. Also, we found that β-catenin signaling increased WAVE2 expression. Therefore, DOCK3 was characterized as a negative regulator of WAVE2 expression via inhibiting β-catenin signaling. Our study provides the first evidence that CD147 promotes tumor cell movement and metastasis via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling axis.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectbeta catenin
dc.subjectCD147 antigen
dc.subjectdedicator of cytokinesis 3 protein
dc.subjectguanine nucleotide exchange factor
dc.subjectlipocortin 2
dc.subjectunclassified drug
dc.subjectWAVE2 protein
dc.subjectANXA2 protein, human
dc.subjectbeta catenin
dc.subjectBSG protein, human
dc.subjectCD147 antigen
dc.subjectCTNNB1 protein, human
dc.subjectDOCK3 protein, human
dc.subjectguanine nucleotide exchange factor
dc.subjectlipocortin 2
dc.subjectmessenger RNA
dc.subjectnerve protein
dc.subjectsmall interfering RNA
dc.subjectWASF2 protein, human
dc.subjectWiskott Aldrich syndrome protein
dc.subjectA549 cell line
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectcell migration
dc.subjectcell motility
dc.subjectcell nucleus
dc.subjectcellular distribution
dc.subjectcontrolled study
dc.subjectdown regulation
dc.subjecthepatocellular carcinoma cell line
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectlamellipodium
dc.subjectliver cell carcinoma
dc.subjectmale
dc.subjectmetastasis
dc.subjectmouse
dc.subjectnonhuman
dc.subjectprotein domain
dc.subjectprotein phosphorylation
dc.subjectprotein protein interaction
dc.subjectsignal transduction
dc.subjectanimal
dc.subjectantagonists and inhibitors
dc.subjectapoptosis
dc.subjectBagg albino mouse
dc.subjectcell motion
dc.subjectcell proliferation
dc.subjectchemistry
dc.subjectdrug screening
dc.subjectfluorescent antibody technique
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectliver tumor
dc.subjectmetabolism
dc.subjectnude mouse
dc.subjectpathology
dc.subjectphosphorylation
dc.subjectreal time polymerase chain reaction
dc.subjectreverse transcription polymerase chain reaction
dc.subjectsecondary
dc.subjectsurface plasmon resonance
dc.subjecttumor cell culture
dc.subjectWestern blotting
dc.subjectAnimals
dc.subjectAnnexin A2
dc.subjectAntigens, CD147
dc.subjectApoptosis
dc.subjectbeta Catenin
dc.subjectBlotting, Western
dc.subjectCarcinoma, Hepatocellular
dc.subjectCell Movement
dc.subjectCell Proliferation
dc.subjectFluorescent Antibody Technique
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectGuanine Nucleotide Exchange Factors
dc.subjectHumans
dc.subjectLiver Neoplasms
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred BALB C
dc.subjectMice, Nude
dc.subjectNerve Tissue Proteins
dc.subjectPhosphorylation
dc.subjectReal-Time Polymerase Chain Reaction
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectRNA, Messenger
dc.subjectRNA, Small Interfering
dc.subjectSignal Transduction
dc.subjectSurface Plasmon Resonance
dc.subjectTumor Cells, Cultured
dc.subjectWiskott-Aldrich Syndrome Protein Family
dc.subjectXenograft Model Antitumor Assays
dc.typeArticle
dc.contributor.departmentDEPT OF PHYSICS
dc.description.doi10.18632/oncotarget.6723
dc.description.sourcetitleOncotarget
dc.description.volume7
dc.description.issue5
dc.description.page5613-5629
dc.published.statePublished
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