Please use this identifier to cite or link to this item: https://doi.org/10.1099/jmm.0.044818-0
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dc.titlePseudomonas aeruginosa outbreaks in the neonatal intensive care unit - a systematic review of risk factors and environmental sources
dc.contributor.authorJefferies, J.M.C
dc.contributor.authorCooper, T
dc.contributor.authorYam, T
dc.contributor.authorClarke, S.C
dc.date.accessioned2020-10-27T04:52:55Z
dc.date.available2020-10-27T04:52:55Z
dc.date.issued2012
dc.identifier.citationJefferies, J.M.C, Cooper, T, Yam, T, Clarke, S.C (2012). Pseudomonas aeruginosa outbreaks in the neonatal intensive care unit - a systematic review of risk factors and environmental sources. Journal of Medical Microbiology 61 (8) : 1052-1061. ScholarBank@NUS Repository. https://doi.org/10.1099/jmm.0.044818-0
dc.identifier.issn0022-2615
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/180826
dc.description.abstractPseudomonas aeruginosa is a Gram-negative bacterium commonly occurring in soil and water. It is an opportunistic pathogen and an important cause of healthcare-associated infections, particularly among infants in neonatal intensive care units (NICUs). Several reports regarding outbreaks of P. aeruginosa in NICUs have been published. MEDLINE and EMBASE databases were searched using the MeSH terms [Pseudomonas aeruginosa], [Outbreak OR Infection OR bacteraemia, OR sepsis OR disease] and [Neonat* OR baby OR babies OR newborn*]. Fifteen studies describing a total of 414 infants colonized or infected with P. aeruginosa were reviewed. The mean percentage of infections occurring in the populations that had been colonized by the organism (calculated as n infected/n infected+n colonized) was 22%. Environmental sampling was performed in 14 studies, nine of which detected P. aeruginosa. The risk factors identified were antimicrobial drug use and the number of days of antimicrobial therapy prescribed before positive blood culture, exposure to particular healthcare workers (HCW), transfusion of blood products, and intravenous delivery of nutrients/electrolytes. Exposure to umbilical venous catheters was associated with bloodstream infections. Increasing age and use of artificial fingernails were risk factors for colonization of hands of HCWs. Low birth weight pre-term infants were at greater risk of mortality from P. aeruginosa infection than older infants. © 2012 SGM.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectantibiotic agent
dc.subjectelectrolyte
dc.subjectfresh frozen plasma
dc.subjectglucose
dc.subjecthuman albumin
dc.subjectantibiotic sensitivity
dc.subjectantibiotic therapy
dc.subjectarticle
dc.subjectbacterial colonization
dc.subjectbacterial growth
dc.subjectbacterial strain
dc.subjectbibliographic database
dc.subjectblood culture
dc.subjectblood transfusion
dc.subjectcatheter infection
dc.subjectdrug delivery system
dc.subjectEmbase
dc.subjectenvironmental factor
dc.subjectepidemic
dc.subjectevidence based medicine
dc.subjectfinger nail
dc.subjecthand
dc.subjecthand washing
dc.subjecthealth care personnel
dc.subjecthuman
dc.subjectintravenous catheter
dc.subjectlow birth weight
dc.subjectMedline
dc.subjectmolecular typing
dc.subjectmortality
dc.subjectmulticenter study (topic)
dc.subjectnewborn
dc.subjectnewborn intensive care
dc.subjectnutrient
dc.subjectparenteral nutrition
dc.subjectprematurity
dc.subjectpriority journal
dc.subjectPseudomonas aeruginosa
dc.subjectPseudomonas infection
dc.subjectrisk factor
dc.subjectsystematic review
dc.subjecttreatment outcome
dc.subjectumbilical vein
dc.subjectCross Infection
dc.subjectDisease Outbreaks
dc.subjectEnvironmental Microbiology
dc.subjectHumans
dc.subjectIntensive Care, Neonatal
dc.subjectPseudomonas aeruginosa
dc.subjectPseudomonas Infections
dc.subjectRisk Factors
dc.typeArticle
dc.contributor.departmentMICROBIOLOGY AND IMMUNOLOGY
dc.description.doi10.1099/jmm.0.044818-0
dc.description.sourcetitleJournal of Medical Microbiology
dc.description.volume61
dc.description.issue8
dc.description.page1052-1061
dc.published.statePublished
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