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Please use this identifier to cite or link to this item: https://doi.org/10.3201/eid1812.120875
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dc.titleTransmission routes for Nipah virus from Malaysia and Bangladesh
dc.contributor.authorClayton, B.A
dc.contributor.authorMiddleton, D
dc.contributor.authorBergfeld, J
dc.contributor.authorHaining, J
dc.contributor.authorArkinstall, R
dc.contributor.authorWang, L
dc.contributor.authorMarsh, G.A
dc.date.accessioned2020-10-27T04:50:24Z
dc.date.available2020-10-27T04:50:24Z
dc.date.issued2012
dc.identifier.citationClayton, B.A, Middleton, D, Bergfeld, J, Haining, J, Arkinstall, R, Wang, L, Marsh, G.A (2012). Transmission routes for Nipah virus from Malaysia and Bangladesh. Emerging Infectious Diseases 18 (12) : 1983-1993. ScholarBank@NUS Repository. https://doi.org/10.3201/eid1812.120875
dc.identifier.issn1080-6040
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/180814
dc.description.abstractHuman infections with Nipah virus in Malaysia and Bangladesh are associated with markedly different patterns of transmission and pathogenicity. To compare the 2 strains, we conducted an in vivo study in which 2 groups of ferrets were oronasally exposed to either the Malaysia or Bangladesh strain of Nipah virus. Viral shedding and tissue tropism were compared between the 2 groups. Over the course of infection, significantly higher levels of viral RNA were recovered from oral secretions of ferrets infected with the Bangladesh strain. Higher levels of oral shedding of the Bangladesh strain of Nipah virus might be a key factor in onward transmission in outbreaks among humans.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectRNA 18S
dc.subjectvirus RNA
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbleeding
dc.subjectdisease course
dc.subjectferret
dc.subjectfever
dc.subjecthistopathology
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectneurologic disease
dc.subjectNipah virus
dc.subjectNipah virus infection
dc.subjectnonhuman
dc.subjectrespiratory tract disease
dc.subjectreverse transcription polymerase chain reaction
dc.subjectviral tropism
dc.subjectvirus load
dc.subjectvirus shedding
dc.subjectvirus transmission
dc.subjectvirus virulence
dc.subjectAnimals
dc.subjectAntigens, Viral
dc.subjectBangladesh
dc.subjectChoroid Plexus
dc.subjectDisease Models, Animal
dc.subjectEndothelial Cells
dc.subjectEndothelium
dc.subjectEpendyma
dc.subjectFerrets
dc.subjectHenipavirus Infections
dc.subjectHumans
dc.subjectMalaysia
dc.subjectMale
dc.subjectNeurons
dc.subjectNipah Virus
dc.subjectPalatine Tonsil
dc.subjectViral Load
dc.subjectVirus Shedding
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.3201/eid1812.120875
dc.description.sourcetitleEmerging Infectious Diseases
dc.description.volume18
dc.description.issue12
dc.description.page1983-1993
dc.published.statePublished
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