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https://doi.org/10.1038/srep09585
DC Field | Value | |
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dc.title | Retinal Vessels Change in Primary Angle-Closure Glaucoma: The Handan Eye Study | |
dc.contributor.author | Gao, J | |
dc.contributor.author | Liang, Y | |
dc.contributor.author | Wang, F | |
dc.contributor.author | Shen, R | |
dc.contributor.author | Wong, T | |
dc.contributor.author | Peng, Y | |
dc.contributor.author | Friedman, D.S | |
dc.contributor.author | Wang, N | |
dc.date.accessioned | 2020-10-26T09:08:01Z | |
dc.date.available | 2020-10-26T09:08:01Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Gao, J, Liang, Y, Wang, F, Shen, R, Wong, T, Peng, Y, Friedman, D.S, Wang, N (2015). Retinal Vessels Change in Primary Angle-Closure Glaucoma: The Handan Eye Study. Scientific Reports 5 : 9585. ScholarBank@NUS Repository. https://doi.org/10.1038/srep09585 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/180472 | |
dc.description.abstract | Glaucoma is the second leading cause of blindness worldwide. To examine the relationship between angle closure and the retinal vessel diameter in Chinese adults, we conducted Handan Eye Study (HES), a large population-based cross-sectional study, which enrolled 6830 participants >30 year-old living in 13 randomly selected villages of Yongnian County. After adjusting for age, gender, spherical equivalent (SE), diabetes, and hypertension, the mean central retinal artery equivalent (CRAE, Î 1/4m) was 127.1 ± 7.0 and 145.6 ± 4.4 in primary open-angle glaucoma (POAG) and primary angle closure glaucoma (PACG), respectively; narrower than that in normal control (156.1 ± 0.4), primary angle-closure suspect (PACS) (156.3 ± 1.1) or primary angle closure (PAC) (156.0 ± 3.4) (P = 0.001). The mean central retinal vein equivalent (CRVE, Î 1/4m) was 229.0 ± 5.9 and 215.8 ± 9.5 in POAG and PACG, respectively; narrower than that in normal control (238.3 ± 0.5), PACS (241.2 ± 1.4) or PAC (242.2 ± 4.6) (P = 0.001). There was no significant difference in the mean CRAE or CRVE between PACG and POAG. Compared to the normal control (0.66), the mean arterio-venous ratio (AVR) was smaller in POAG (0.64) and PACG (0.59), whereas larger in PACS (0.65) and PAC (0.67) (P = 0.003). To conclude, PACG and POAG individuals have narrower retinal arteries and veins. | |
dc.publisher | Nature Publishing Group | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | blindness | |
dc.subject | case control study | |
dc.subject | China | |
dc.subject | cross-sectional study | |
dc.subject | female | |
dc.subject | human | |
dc.subject | intraocular pressure | |
dc.subject | male | |
dc.subject | middle aged | |
dc.subject | open angle glaucoma | |
dc.subject | pathology | |
dc.subject | physiology | |
dc.subject | retina blood vessel | |
dc.subject | visual field | |
dc.subject | Blindness | |
dc.subject | Case-Control Studies | |
dc.subject | China | |
dc.subject | Cross-Sectional Studies | |
dc.subject | Female | |
dc.subject | Glaucoma, Open-Angle | |
dc.subject | Humans | |
dc.subject | Intraocular Pressure | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Retinal Vessels | |
dc.subject | Visual Fields | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1038/srep09585 | |
dc.description.sourcetitle | Scientific Reports | |
dc.description.volume | 5 | |
dc.description.page | 9585 | |
dc.published.state | published | |
Appears in Collections: | Elements Staff Publications |
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