Please use this identifier to cite or link to this item:
https://doi.org/10.7554/eLife.05558
DC Field | Value | |
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dc.title | A cortical disinhibitory circuit for enhancing adult plasticity | |
dc.contributor.author | Fu, Y | |
dc.contributor.author | Kaneko, M | |
dc.contributor.author | Tang, Y | |
dc.contributor.author | Alvarez-Buylla, A | |
dc.contributor.author | Stryker, M.P | |
dc.date.accessioned | 2020-10-26T08:31:14Z | |
dc.date.available | 2020-10-26T08:31:14Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Fu, Y, Kaneko, M, Tang, Y, Alvarez-Buylla, A, Stryker, M.P (2015). A cortical disinhibitory circuit for enhancing adult plasticity. eLife 2015 (4). ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.05558 | |
dc.identifier.issn | 2050084X | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/180346 | |
dc.description.abstract | The adult brain continues to learn and can recover from injury, but the elements and operation of the neural circuits responsible for this plasticity are not known. In previous work we have: shown that locomotion dramatically enhances neural activity in the visual cortex (V1) of the mouse (Neill and Stryker, 2010); identified the cortical circuit responsible for this enhancement (Fu et al., 2014); and shown that locomotion also dramatically enhances adult plasticity (Kaneko & Stryker, 2014). The circuit responsible that is responsible for enhancing neural activity in the visual cortex contains both vasoactive intestinal peptide (VIP) and somatostatin (SST) neurons (Fu et al., 2014). Here we ask whether this VIP-SST circuit enhances plasticity directly, independent of locomotion and aerobic activity. Optogenetic activation or genetic blockade of this circuit reveal that it is both necessary and sufficient for rapidly increasing V1 cortical responses following manipulation of visual experience in adult mice. These findings reveal a disinhibitory circuit that regulates adult cortical plasticity. © 2015, eLife Sciences Publications Ltd. All rights reserved. | |
dc.relation.isreplacedby | hdl:10635/179380 | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | somatostatin | |
dc.subject | vasoactive intestinal polypeptide | |
dc.subject | somatostatin | |
dc.subject | vasoactive intestinal polypeptide | |
dc.subject | adult | |
dc.subject | animal experiment | |
dc.subject | animal tissue | |
dc.subject | Article | |
dc.subject | brain electrophysiology | |
dc.subject | brain tissue | |
dc.subject | controlled study | |
dc.subject | female | |
dc.subject | fiber optic cannula implantation | |
dc.subject | fluorescence imaging | |
dc.subject | immunohistochemistry | |
dc.subject | implantation | |
dc.subject | locomotion | |
dc.subject | male | |
dc.subject | monocular deprivation | |
dc.subject | mouse | |
dc.subject | nerve block | |
dc.subject | nerve cell plasticity | |
dc.subject | nonhuman | |
dc.subject | optogenetics | |
dc.subject | synaptic transmission | |
dc.subject | tetrode recording | |
dc.subject | virus | |
dc.subject | visual cortex | |
dc.subject | visual stimulation | |
dc.subject | aging | |
dc.subject | animal | |
dc.subject | C57BL mouse | |
dc.subject | eye dominance | |
dc.subject | metabolism | |
dc.subject | nerve cell | |
dc.subject | nerve cell inhibition | |
dc.subject | nerve cell plasticity | |
dc.subject | physiology | |
dc.subject | running | |
dc.subject | Mus | |
dc.subject | Aging | |
dc.subject | Animals | |
dc.subject | Dominance, Ocular | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Neural Inhibition | |
dc.subject | Neuronal Plasticity | |
dc.subject | Neurons | |
dc.subject | Running | |
dc.subject | Somatostatin | |
dc.subject | Synaptic Transmission | |
dc.subject | Vasoactive Intestinal Peptide | |
dc.subject | Visual Cortex | |
dc.type | Article | |
dc.contributor.department | PHYSIOLOGY | |
dc.description.doi | 10.7554/eLife.05558 | |
dc.description.sourcetitle | eLife | |
dc.description.volume | 2015 | |
dc.description.issue | 4 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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