Please use this identifier to cite or link to this item:
https://doi.org/10.1111/anae.12973
DC Field | Value | |
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dc.title | Remote ischaemic conditioning: Cardiac protection from afar | |
dc.contributor.author | Sivaraman, V | |
dc.contributor.author | Pickard, J.M.J | |
dc.contributor.author | Hausenloy, D.J | |
dc.date.accessioned | 2020-10-26T07:03:38Z | |
dc.date.available | 2020-10-26T07:03:38Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Sivaraman, V, Pickard, J.M.J, Hausenloy, D.J (2015). Remote ischaemic conditioning: Cardiac protection from afar. Anaesthesia 70 (6) : 732-748. ScholarBank@NUS Repository. https://doi.org/10.1111/anae.12973 | |
dc.identifier.issn | 0003-2409 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/180119 | |
dc.description.abstract | For patients with ischaemic heart disease, remote ischaemic conditioning may offer an innovative, non-invasive and virtually cost-free therapy for protecting the myocardium against the detrimental effects of acute ischaemia-reperfusion injury, preserving cardiac function and improving clinical outcomes. The intriguing phenomenon of remote ischaemic conditioning was first discovered over 20 years ago, when it was shown that the heart could be rendered resistant to acute ischaemia-reperfusion injury by applying one or more cycles of brief ischaemia and reperfusion to an organ or tissue away from the heart - initially termed 'cardioprotection at a distance'. Subsequent pre-clinical and then clinical studies made the important discovery that remote ischaemic conditioning could be elicited non-invasively, by inducing brief ischaemia and reperfusion to the upper or lower limb using a cuff. The actual mechanism underlying remote ischaemic conditioning cardioprotection remains unclear, although a neuro-hormonal pathway has been implicated. Since its initial discovery in 1993, the first proof-of-concept clinical studies of remote ischaemic conditioning followed in 2006, and now multicentre clinical outcome studies are underway. In this review article, we explore the potential mechanisms underlying this academic curiosity, and assess the success of its application in the clinical setting. © 2015 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists of Great Britain and Ireland. | |
dc.publisher | Blackwell Publishing Ltd | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | anesthetic agent | |
dc.subject | anesthesia | |
dc.subject | anesthesia induction | |
dc.subject | coronary artery bypass graft | |
dc.subject | heart muscle injury | |
dc.subject | heart muscle reperfusion | |
dc.subject | heart protection | |
dc.subject | heart surgery | |
dc.subject | human | |
dc.subject | intracellular signaling | |
dc.subject | ischemic postconditioning | |
dc.subject | ischemic preconditioning | |
dc.subject | multicenter study (topic) | |
dc.subject | non invasive procedure | |
dc.subject | nonhuman | |
dc.subject | randomized controlled trial (topic) | |
dc.subject | remote ischemic conditioning | |
dc.subject | reperfusion injury | |
dc.subject | Review | |
dc.subject | ST segment elevation myocardial infarction | |
dc.subject | vascular surgery | |
dc.subject | animal | |
dc.subject | heart infarction prevention | |
dc.subject | Myocardial Reperfusion Injury | |
dc.subject | procedures | |
dc.subject | teleconsultation | |
dc.subject | telemedicine | |
dc.subject | thorax surgery | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Ischemic Preconditioning, Myocardial | |
dc.subject | Myocardial Reperfusion Injury | |
dc.subject | Remote Consultation | |
dc.subject | Telemedicine | |
dc.subject | Thoracic Surgery | |
dc.type | Review | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1111/anae.12973 | |
dc.description.sourcetitle | Anaesthesia | |
dc.description.volume | 70 | |
dc.description.issue | 6 | |
dc.description.page | 732-748 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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