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Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.9333
DC FieldValue
dc.titleThe emerging roles of exosomes in leukemogeneis
dc.contributor.authorZhou, J
dc.contributor.authorWang, S
dc.contributor.authorSun, K
dc.contributor.authorChng, W.-J
dc.date.accessioned2020-10-26T05:19:28Z
dc.date.available2020-10-26T05:19:28Z
dc.date.issued2016
dc.identifier.citationZhou, J, Wang, S, Sun, K, Chng, W.-J (2016). The emerging roles of exosomes in leukemogeneis. Oncotarget 7 (31) : 50698-50707. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.9333
dc.identifier.issn19492553
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/179969
dc.description.abstractCommunication between leukemia cells and their environment is essential for the development and progression of leukemia. Exosomes are microvesicles secreted by many types of cells that contain protein and RNA and mediate intercellular communication. The involvement of exosomes has been demonstrated in the crosstalk between leukemic cells, stromal cells and endothelial cells, consequently promoting the survival of leukemic cells, protection of leukemic cells from the cytotoxic effects of chemotherapeutic drugs, angiogenesis and cell migration. At the same time, exosomes can be used for the detection and monitoring of leukemia, with some advantage over current methods of detection and surveillance. As they are involved in immune response towards leukemic cells, exosomes can also potentially be exploited to augment immunotherapy in leukemia. In this review, we first describe the general characteristics of exosomes and biogenesis of exosomes. We then highlight the emerging role of exosomes in different types of leukemia. Finally, the clinical value of exosomes as biomarkers, in vivo drug carriers and novel exosome-based immunotherapy are discussed.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectbiological marker
dc.subjectgalectin 3
dc.subjectmicroRNA 126
dc.subjectsomatomedin C receptor
dc.subjecttransforming growth factor beta receptor 1
dc.subjectantineoplastic agent
dc.subjectprotein
dc.subjectRNA
dc.subjectacute myeloblastic leukemia
dc.subjectapoptosis
dc.subjectbiogenesis
dc.subjectbone marrow biopsy
dc.subjectbone marrow stroma cell
dc.subjectcancer chemotherapy
dc.subjectcancer diagnosis
dc.subjectcancer immunotherapy
dc.subjectcancer prognosis
dc.subjectcancer resistance
dc.subjectcell proliferation
dc.subjectcell survival
dc.subjectchronic lymphatic leukemia
dc.subjectchronic myeloid leukemia
dc.subjectdendritic cell
dc.subjectdrug delivery system
dc.subjectexosome
dc.subjectflow cytometry
dc.subjectgraft versus host reaction
dc.subjecthuman
dc.subjectimmune response
dc.subjectin vivo study
dc.subjectleukemia
dc.subjectleukemia cell
dc.subjectleukemogenesis
dc.subjectmesenchymal stem cell
dc.subjectnonhuman
dc.subjectReview
dc.subjecttumor escape
dc.subjecttumor microenvironment
dc.subjecttumor vascularization
dc.subjectanimal
dc.subjectcell communication
dc.subjectcell motion
dc.subjectdrug resistance
dc.subjectendosome
dc.subjectexosome
dc.subjectgene expression regulation
dc.subjectimmunotherapy
dc.subjectleukemia
dc.subjectmetabolism
dc.subjectmouse
dc.subjectneovascularization (pathology)
dc.subjectprognosis
dc.subjecttreatment outcome
dc.subjectAnimals
dc.subjectAntineoplastic Agents
dc.subjectCell Communication
dc.subjectCell Movement
dc.subjectCell Proliferation
dc.subjectCell Survival
dc.subjectDrug Resistance, Neoplasm
dc.subjectEndosomes
dc.subjectExosomes
dc.subjectGene Expression Regulation, Leukemic
dc.subjectHumans
dc.subjectImmunotherapy
dc.subjectLeukemia
dc.subjectMice
dc.subjectNeovascularization, Pathologic
dc.subjectPrognosis
dc.subjectProteins
dc.subjectRNA
dc.subjectTreatment Outcome
dc.typeReview
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentMEDICINE
dc.description.doi10.18632/oncotarget.9333
dc.description.sourcetitleOncotarget
dc.description.volume7
dc.description.issue31
dc.description.page50698-50707
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