Please use this identifier to cite or link to this item:
https://doi.org/10.1038/bcj.2017.67
Title: | Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia | Authors: | Hou, H.-A Lu, J.-W Lin, T.-Y Tsai, C.-H Chou, W.-C Lin, C.-C Kuo, Y.-Y Liu, C.-Y Tseng, M.-H Chiang, Y.-C Peng, Y.-L Tang, J.-L Gong, Z Lin, L.-I Tien, H.-F |
Keywords: | SOCS1 protein, human SOCS1 protein, zebrafish suppressor of cytokine signaling 1 tumor marker tumor protein zebrafish protein acute myeloid leukemia adolescent adult aged animal biosynthesis clinical trial disease free survival genetics human male metabolism middle aged mortality pathology survival rate transgenic animal very elderly zebra fish Adolescent Adult Aged Aged, 80 and over Animals Animals, Genetically Modified Biomarkers, Tumor Disease-Free Survival Humans Leukemia, Myeloid, Acute Male Middle Aged Neoplasm Proteins Suppressor of Cytokine Signaling 1 Protein Survival Rate Zebrafish Zebrafish Proteins |
Issue Date: | 2017 | Citation: | Hou, H.-A, Lu, J.-W, Lin, T.-Y, Tsai, C.-H, Chou, W.-C, Lin, C.-C, Kuo, Y.-Y, Liu, C.-Y, Tseng, M.-H, Chiang, Y.-C, Peng, Y.-L, Tang, J.-L, Gong, Z, Lin, L.-I, Tien, H.-F (2017). Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia. Blood cancer journal 7 (7) : e588. ScholarBank@NUS Repository. https://doi.org/10.1038/bcj.2017.67 | Rights: | Attribution 4.0 International | Abstract: | Suppressor of cytokine signaling 1 (SOCS1) protein, which encodes a member of signal transducers and activators of transcription-induced inhibitors, takes part in a negative regulation of cytokine signaling. The mechanism of SOCS1 in tumor carcinogenesis is complex and there have been no studies concerning the clinic-biologic implication of SOCS1 expression in acute myeloid leukemia (AML). Here, we first identified that higher bone marrow (BM) SOCS1 expression was closely associated with older age, FLT3-ITD, NPM1 and DNMT3A mutations, but negatively correlated with CEBPA mutation in patients with de novo AML. Compared to patients with lower SOCS1 expression, those with higher expression had lower complete remission rates and shorter overall survival. Further, higher expression of SOCS1 in the BM was an independent unfavorable prognostic factor irrespective of age, white blood cell, cytogenetics and gene mutations. Next, we generated zebrafish model overexpressing SOCS1 by spi1 promoter, which showed kidney marrow from adult SOCS1 zebrafish had increased myelopoiesis, myeloid progenitors and the kidney or spleen structure were effaced and distorted, mimicking leukemia phenotype. The SOCS1/FLT3-ITD double transgenic fish could further facilitate the leukemic process. The results indicate SOCS1 plays an important role in AML and its higher expression serves as a new biomarker to risk-stratify AML patients. | Source Title: | Blood cancer journal | URI: | https://scholarbank.nus.edu.sg/handle/10635/179705 | ISSN: | 2044-5385 | DOI: | 10.1038/bcj.2017.67 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1038_bcj_2017_67.pdf | 3.66 MB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License