Please use this identifier to cite or link to this item:
https://doi.org/10.1084/jem.20170484
DC Field | Value | |
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dc.title | JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia | |
dc.contributor.author | Mansour, M.R | |
dc.contributor.author | He, S | |
dc.contributor.author | Li, Z | |
dc.contributor.author | Lobbardi, R | |
dc.contributor.author | Abraham, B.J | |
dc.contributor.author | Hug, C | |
dc.contributor.author | Rahman, S | |
dc.contributor.author | Leon, T.E | |
dc.contributor.author | Kuang, Y.-Y | |
dc.contributor.author | Zimmerman, M.W | |
dc.contributor.author | Blonquist, T | |
dc.contributor.author | Gjini, E | |
dc.contributor.author | Gutierrez, A | |
dc.contributor.author | Tang, Q | |
dc.contributor.author | Garcia Perez, L | |
dc.contributor.author | Pike Overzet, K | |
dc.contributor.author | Anders, L | |
dc.contributor.author | Berezovskaya, A | |
dc.contributor.author | Zhou, Y | |
dc.contributor.author | Zon, L.I | |
dc.contributor.author | Neuberg, D | |
dc.contributor.author | Fielding, A.K | |
dc.contributor.author | Staal, F.J.T | |
dc.contributor.author | Langenau, D.M | |
dc.contributor.author | Sanda, T | |
dc.contributor.author | Young, R.A | |
dc.contributor.author | Look, A.T | |
dc.date.accessioned | 2020-10-22T07:22:29Z | |
dc.date.available | 2020-10-22T07:22:29Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Mansour, M.R, He, S, Li, Z, Lobbardi, R, Abraham, B.J, Hug, C, Rahman, S, Leon, T.E, Kuang, Y.-Y, Zimmerman, M.W, Blonquist, T, Gjini, E, Gutierrez, A, Tang, Q, Garcia Perez, L, Pike Overzet, K, Anders, L, Berezovskaya, A, Zhou, Y, Zon, L.I, Neuberg, D, Fielding, A.K, Staal, F.J.T, Langenau, D.M, Sanda, T, Young, R.A, Look, A.T (2018). JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. Journal of Experimental Medicine 215 (7) : 1929-1945. ScholarBank@NUS Repository. https://doi.org/10.1084/jem.20170484 | |
dc.identifier.issn | 00221007 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/179029 | |
dc.description.abstract | A substantial subset of patients with T cell acute lymphoblastic leukemia (T-ALL) develops resistance to steroids and succumbs to their disease. JDP2 encodes a bZIP protein that has been implicated as a T-ALL oncogene from insertional mutagenesis studies in mice, but its role in human T-ALL pathogenesis has remained obscure. Here we show that JDP2 is aberrantly expressed in a subset of T-ALL patients and is associated with poor survival. JDP2 is required for T-ALL cell survival, as its depletion by short hairpin RNA knockdown leads to apoptosis. Mechanistically, JDP2 regulates prosurvival signaling through direct transcriptional regulation of MCL1. Furthermore, JDP2 is one of few oncogenes capable of initiating T-ALL in transgenic zebrafish. Notably, thymocytes from rag2:jdp2 transgenic zebrafish express high levels of mcl1 and demonstrate resistance to steroids in vivo. These studies establish JDP2 as a novel oncogene in high-risk T-ALL and implicate overexpression of MCL1 as a mechanism of steroid resistance in JDP2-overexpressing cells. © 2018 Mansour et al. | |
dc.publisher | Rockefeller University Press | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | basic leucine zipper transcription factor | |
dc.subject | caspase 3 | |
dc.subject | ccnd2 protein | |
dc.subject | dexamethasone | |
dc.subject | doxycycline | |
dc.subject | glucocorticoid | |
dc.subject | jdp2 protein | |
dc.subject | microRNA 17 92 | |
dc.subject | Myc protein | |
dc.subject | nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1 | |
dc.subject | Notch1 receptor | |
dc.subject | protein | |
dc.subject | protein kinase B | |
dc.subject | protein kinase Pim 1 | |
dc.subject | protein mcl 1 | |
dc.subject | protein Myb | |
dc.subject | RAG2 protein | |
dc.subject | short hairpin RNA | |
dc.subject | steroid | |
dc.subject | transcription factor RUNX2 | |
dc.subject | unclassified drug | |
dc.subject | zinc finger E box binding homeobox 2 | |
dc.subject | dexamethasone | |
dc.subject | glucocorticoid | |
dc.subject | JDP2 protein, human | |
dc.subject | MCL1 protein, human | |
dc.subject | Myc protein | |
dc.subject | protein binding | |
dc.subject | protein mcl 1 | |
dc.subject | repressor protein | |
dc.subject | zebrafish protein | |
dc.subject | acute lymphoblastic leukemia | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | apoptosis | |
dc.subject | Article | |
dc.subject | cancer survival | |
dc.subject | cell survival | |
dc.subject | controlled study | |
dc.subject | disease association | |
dc.subject | genetic association | |
dc.subject | human | |
dc.subject | human tissue | |
dc.subject | in vivo study | |
dc.subject | nonhuman | |
dc.subject | oncogene | |
dc.subject | priority journal | |
dc.subject | protein expression | |
dc.subject | regulatory mechanism | |
dc.subject | signal transduction | |
dc.subject | thymocyte | |
dc.subject | transgenic zebrafish | |
dc.subject | upregulation | |
dc.subject | acute lymphoblastic leukemia | |
dc.subject | animal | |
dc.subject | cancer transplantation | |
dc.subject | cell proliferation | |
dc.subject | disease model | |
dc.subject | DNA responsive element | |
dc.subject | drug effect | |
dc.subject | enhancer region | |
dc.subject | gene expression regulation | |
dc.subject | genetics | |
dc.subject | infant | |
dc.subject | metabolism | |
dc.subject | mouse | |
dc.subject | nucleotide sequence | |
dc.subject | oncogene | |
dc.subject | pathology | |
dc.subject | preschool child | |
dc.subject | treatment outcome | |
dc.subject | zebra fish | |
dc.subject | Animals | |
dc.subject | Apoptosis | |
dc.subject | Base Sequence | |
dc.subject | Cell Proliferation | |
dc.subject | Cell Survival | |
dc.subject | Child, Preschool | |
dc.subject | Dexamethasone | |
dc.subject | Disease Models, Animal | |
dc.subject | Enhancer Elements, Genetic | |
dc.subject | Gene Expression Regulation, Leukemic | |
dc.subject | Glucocorticoids | |
dc.subject | Humans | |
dc.subject | Infant | |
dc.subject | Mice | |
dc.subject | Mutagenesis, Insertional | |
dc.subject | Myeloid Cell Leukemia Sequence 1 Protein | |
dc.subject | Neoplasm Transplantation | |
dc.subject | Oncogenes | |
dc.subject | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | |
dc.subject | Protein Binding | |
dc.subject | Proto-Oncogene Proteins c-myc | |
dc.subject | Repressor Proteins | |
dc.subject | Response Elements | |
dc.subject | Thymocytes | |
dc.subject | Treatment Outcome | |
dc.subject | Zebrafish | |
dc.subject | Zebrafish Proteins | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.1084/jem.20170484 | |
dc.description.sourcetitle | Journal of Experimental Medicine | |
dc.description.volume | 215 | |
dc.description.issue | 7 | |
dc.description.page | 1929-1945 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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