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https://doi.org/10.1038/srep26097
DC Field | Value | |
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dc.title | Early clearance of Chikungunya virus in children is associated with a strong innate immune response | |
dc.contributor.author | Simarmata, D | |
dc.contributor.author | Ng, D.C.E | |
dc.contributor.author | Kam, Y.-W | |
dc.contributor.author | Lee, B | |
dc.contributor.author | Sum, M.S.H | |
dc.contributor.author | Her, Z | |
dc.contributor.author | Chow, A | |
dc.contributor.author | Leo, Y.-S | |
dc.contributor.author | Cardosa, J | |
dc.contributor.author | Perera, D | |
dc.contributor.author | Ooi, M.H | |
dc.contributor.author | Ng, L.F.P | |
dc.date.accessioned | 2020-10-22T02:58:54Z | |
dc.date.available | 2020-10-22T02:58:54Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Simarmata, D, Ng, D.C.E, Kam, Y.-W, Lee, B, Sum, M.S.H, Her, Z, Chow, A, Leo, Y.-S, Cardosa, J, Perera, D, Ooi, M.H, Ng, L.F.P (2016). Early clearance of Chikungunya virus in children is associated with a strong innate immune response. Scientific Reports 6 : 26097. ScholarBank@NUS Repository. https://doi.org/10.1038/srep26097 | |
dc.identifier.issn | 20452322 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/178910 | |
dc.description.abstract | Chikungunya fever (CHIKF) is a global infectious disease which can affect a wide range of age groups. The pathological and immunological response upon Chikungunya virus (CHIKV) infection have been reported over the last few years. However, the clinical profile and immune response upon CHIKV infection in children remain largely unknown. In this study, we analyzed the clinical and immunological response, focusing on the cytokine/chemokine profile in a CHIKV-infected pediatric cohort from Sarawak, Malaysia. Unique immune mediators triggered upon CHIKV infection were identified through meta-analysis of the immune signatures between this pediatric group and cohorts from previous outbreaks. The data generated from this study revealed that a broad spectrum of cytokines/chemokines is up-regulated in a sub-group of virus-infected children stratified according to their viremic status during hospitalization. Furthermore, different immune mediator profiles (the levels of pro-inflammatory cytokines, chemokines and growth and other factors) were observed between children and adults. This study gives an important insight to understand the immune response of CHIKV infection in children and would aid in the development of better prognostics and clinical management for children. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | autacoid | |
dc.subject | cytokine | |
dc.subject | signal peptide | |
dc.subject | adult | |
dc.subject | chikungunya | |
dc.subject | Chikungunya virus | |
dc.subject | child | |
dc.subject | cohort analysis | |
dc.subject | female | |
dc.subject | human | |
dc.subject | immunology | |
dc.subject | infant | |
dc.subject | innate immunity | |
dc.subject | Malaysia | |
dc.subject | male | |
dc.subject | meta analysis | |
dc.subject | metabolism | |
dc.subject | physiology | |
dc.subject | preschool child | |
dc.subject | viremia | |
dc.subject | virus load | |
dc.subject | Adult | |
dc.subject | Chikungunya Fever | |
dc.subject | Chikungunya virus | |
dc.subject | Child | |
dc.subject | Child, Preschool | |
dc.subject | Cohort Studies | |
dc.subject | Cytokines | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Immunity, Innate | |
dc.subject | Infant | |
dc.subject | Inflammation Mediators | |
dc.subject | Intercellular Signaling Peptides and Proteins | |
dc.subject | Malaysia | |
dc.subject | Male | |
dc.subject | Viral Load | |
dc.subject | Viremia | |
dc.type | Article | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.doi | 10.1038/srep26097 | |
dc.description.sourcetitle | Scientific Reports | |
dc.description.volume | 6 | |
dc.description.page | 26097 | |
Appears in Collections: | Elements Staff Publications |
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