Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep26097
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dc.titleEarly clearance of Chikungunya virus in children is associated with a strong innate immune response
dc.contributor.authorSimarmata, D
dc.contributor.authorNg, D.C.E
dc.contributor.authorKam, Y.-W
dc.contributor.authorLee, B
dc.contributor.authorSum, M.S.H
dc.contributor.authorHer, Z
dc.contributor.authorChow, A
dc.contributor.authorLeo, Y.-S
dc.contributor.authorCardosa, J
dc.contributor.authorPerera, D
dc.contributor.authorOoi, M.H
dc.contributor.authorNg, L.F.P
dc.date.accessioned2020-10-22T02:58:54Z
dc.date.available2020-10-22T02:58:54Z
dc.date.issued2016
dc.identifier.citationSimarmata, D, Ng, D.C.E, Kam, Y.-W, Lee, B, Sum, M.S.H, Her, Z, Chow, A, Leo, Y.-S, Cardosa, J, Perera, D, Ooi, M.H, Ng, L.F.P (2016). Early clearance of Chikungunya virus in children is associated with a strong innate immune response. Scientific Reports 6 : 26097. ScholarBank@NUS Repository. https://doi.org/10.1038/srep26097
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178910
dc.description.abstractChikungunya fever (CHIKF) is a global infectious disease which can affect a wide range of age groups. The pathological and immunological response upon Chikungunya virus (CHIKV) infection have been reported over the last few years. However, the clinical profile and immune response upon CHIKV infection in children remain largely unknown. In this study, we analyzed the clinical and immunological response, focusing on the cytokine/chemokine profile in a CHIKV-infected pediatric cohort from Sarawak, Malaysia. Unique immune mediators triggered upon CHIKV infection were identified through meta-analysis of the immune signatures between this pediatric group and cohorts from previous outbreaks. The data generated from this study revealed that a broad spectrum of cytokines/chemokines is up-regulated in a sub-group of virus-infected children stratified according to their viremic status during hospitalization. Furthermore, different immune mediator profiles (the levels of pro-inflammatory cytokines, chemokines and growth and other factors) were observed between children and adults. This study gives an important insight to understand the immune response of CHIKV infection in children and would aid in the development of better prognostics and clinical management for children.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectautacoid
dc.subjectcytokine
dc.subjectsignal peptide
dc.subjectadult
dc.subjectchikungunya
dc.subjectChikungunya virus
dc.subjectchild
dc.subjectcohort analysis
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunology
dc.subjectinfant
dc.subjectinnate immunity
dc.subjectMalaysia
dc.subjectmale
dc.subjectmeta analysis
dc.subjectmetabolism
dc.subjectphysiology
dc.subjectpreschool child
dc.subjectviremia
dc.subjectvirus load
dc.subjectAdult
dc.subjectChikungunya Fever
dc.subjectChikungunya virus
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCohort Studies
dc.subjectCytokines
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunity, Innate
dc.subjectInfant
dc.subjectInflammation Mediators
dc.subjectIntercellular Signaling Peptides and Proteins
dc.subjectMalaysia
dc.subjectMale
dc.subjectViral Load
dc.subjectViremia
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.description.doi10.1038/srep26097
dc.description.sourcetitleScientific Reports
dc.description.volume6
dc.description.page26097
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