Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s13578-016-0113-7
DC Field | Value | |
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dc.title | Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD | |
dc.contributor.author | Sinha, R.A | |
dc.contributor.author | Yen, P.M | |
dc.date.accessioned | 2020-10-22T02:54:07Z | |
dc.date.available | 2020-10-22T02:54:07Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Sinha, R.A, Yen, P.M (2016). Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD. Cell and Bioscience 6 (1) : 46. ScholarBank@NUS Repository. https://doi.org/10.1186/s13578-016-0113-7 | |
dc.identifier.issn | 20453701 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/178889 | |
dc.description.abstract | Non-alcoholic fatty liver disease (NAFLD) is a fast-growing silent epidemic that is present in both developed and developing countries. Initially thought as a benign deposition of lipids in the liver, it now has been shown to be a major risk factor for type II diabetes and one of the leading causes of cirrhosis. Recent findings suggest that dysregulation of mitochondrial homeostasis and autophagy play critical roles in the hepatocyte injury and insulin resistance of NAFLD. Thyroid hormone (TH) is a major stimulator of hepatic autophagy and mitochondrial function. Decreased TH action has been associated with NAFLD in man. In this review, we highlight some of the new discoveries that demonstrate the roles of TH in hepatic mitochondrial homeostasis via mitophagy and their implications for NAFLD. © 2016 The Author(s). | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.type | Review | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1186/s13578-016-0113-7 | |
dc.description.sourcetitle | Cell and Bioscience | |
dc.description.volume | 6 | |
dc.description.issue | 1 | |
dc.description.page | 46 | |
Appears in Collections: | Elements Staff Publications |
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