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Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-017-00737-8
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dc.titleA single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage
dc.contributor.authorShan, C
dc.contributor.authorMuruato, A.E
dc.contributor.authorJagger, B.W
dc.contributor.authorRichner, J
dc.contributor.authorNunes, B.T.D
dc.contributor.authorMedeiros, D.B.A
dc.contributor.authorXie, X
dc.contributor.authorNunes, J.G.C
dc.contributor.authorMorabito, K.M
dc.contributor.authorKong, W.-P
dc.contributor.authorPierson, T.C
dc.contributor.authorBarrett, A.D
dc.contributor.authorWeaver, S.C
dc.contributor.authorRossi, S.L
dc.contributor.authorVasconcelos, P.F.C
dc.contributor.authorGraham, B.S
dc.contributor.authorDiamond, M.S
dc.contributor.authorShi, P.-Y
dc.date.accessioned2020-10-20T10:23:00Z
dc.date.available2020-10-20T10:23:00Z
dc.date.issued2017
dc.identifier.citationShan, C, Muruato, A.E, Jagger, B.W, Richner, J, Nunes, B.T.D, Medeiros, D.B.A, Xie, X, Nunes, J.G.C, Morabito, K.M, Kong, W.-P, Pierson, T.C, Barrett, A.D, Weaver, S.C, Rossi, S.L, Vasconcelos, P.F.C, Graham, B.S, Diamond, M.S, Shi, P.-Y (2017). A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage. Nature Communications 8 (1) : 676. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-017-00737-8
dc.identifier.issn2041-1723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178574
dc.description.abstractZika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3? untranslated region of the Zika virus genome (ZIKV-3?UTR-LAV) prevent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primates. After a single-dose vaccination, pregnant mice challenged with Zika virus at embryonic day 6 and evaluated at embryonic day 13 show markedly diminished levels of viral RNA in maternal, placental, and fetal tissues. Vaccinated male mice challenged with Zika virus were protected against testis infection, injury, and oligospermia. A single immunization of rhesus macaques elicited a rapid and robust antibody response, conferring complete protection upon challenge. Furthermore, the ZIKV-3?UTR-LAV vaccine candidates have a desirable safety profile. These results suggest that further development of ZIKV-3?UTR-LAV is warranted for humans. © 2017 The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectlive vaccine
dc.subjectneutralizing antibody
dc.subjectvirus RNA
dc.subjectZika virus vaccine
dc.subjectlive vaccine
dc.subjectvirus vaccine
dc.subjectabnormality
dc.subjectdisease transmission
dc.subjectembryo
dc.subjectembryonic development
dc.subjectgenome
dc.subjectimmunization
dc.subjectinfectious disease
dc.subjectmale
dc.subjectnervous system disorder
dc.subjectpregnancy
dc.subjectprimate
dc.subjectreproductive health
dc.subjectrodent
dc.subjectsexually transmitted disease
dc.subjectvaccine
dc.subjectvirus
dc.subjectZika virus disease
dc.subject3' untranslated region
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantibody blood level
dc.subjectantibody response
dc.subjectantibody titer
dc.subjectArticle
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectembryo
dc.subjectfemale
dc.subjectfetus
dc.subjectfetus tissue
dc.subjectfocus forming assay
dc.subjectgene deletion
dc.subjectlimit of detection
dc.subjectmale
dc.subjectmaternal blood
dc.subjectmouse
dc.subjectnonhuman
dc.subjectoligospermia
dc.subjectorchitis
dc.subjectplacenta tissue
dc.subjectpregnancy
dc.subjectrhesus monkey
dc.subjectsingle drug dose
dc.subjectspermatozoon count
dc.subjectspermatozoon motility
dc.subjecttestis injury
dc.subjectvaccination
dc.subjectvaccine immunogenicity
dc.subjectvertical transmission
dc.subjectvirus genome
dc.subjectvirus load
dc.subjectvirus replication
dc.subjectvirus transmission
dc.subjectZika fever
dc.subjectanimal
dc.subjectC57BL mouse
dc.subjectgenetics
dc.subjectimmunology
dc.subjectpathology
dc.subjectpreclinical study
dc.subjectpregnancy
dc.subjectprevention and control
dc.subjecttestis
dc.subjecttransmission
dc.subjectvertical transmission
dc.subjectvirology
dc.subjectZika fever
dc.subjectZika virus
dc.subjectHuman immunodeficiency virus 1
dc.subjectMacaca mulatta
dc.subjectMus
dc.subjectPrimates
dc.subjectZika virus
dc.subjectAnimals
dc.subjectDrug Evaluation, Preclinical
dc.subjectFemale
dc.subjectInfectious Disease Transmission, Vertical
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectPregnancy
dc.subjectTestis
dc.subjectVaccines, Attenuated
dc.subjectViral Vaccines
dc.subjectZika Virus
dc.subjectZika Virus Infection
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41467-017-00737-8
dc.description.sourcetitleNature Communications
dc.description.volume8
dc.description.issue1
dc.description.page676
dc.published.statepublished
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