Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-21612-6
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dc.titleMetformin Use and Severe Dengue in Diabetic Adults
dc.contributor.authorHtun, H.L
dc.contributor.authorYeo, T.W
dc.contributor.authorTam, C.C
dc.contributor.authorPang, J
dc.contributor.authorLeo, Y.S
dc.contributor.authorLye, D.C
dc.date.accessioned2020-10-20T09:55:55Z
dc.date.available2020-10-20T09:55:55Z
dc.date.issued2018
dc.identifier.citationHtun, H.L, Yeo, T.W, Tam, C.C, Pang, J, Leo, Y.S, Lye, D.C (2018). Metformin Use and Severe Dengue in Diabetic Adults. Scientific Reports 8 (1) : 3344. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-21612-6
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178429
dc.description.abstractDiabetes mellitus is a risk factor for severe dengue in adults, but few studies have examined the association between metformin use and disease severity in dengue. In addition to its effect on glucose control, metformin has been associated with pleiotropic properties in preclinical studies. Using a cohort of laboratory-confirmed adult (?21 years) dengue patients with diabetes mellitus admitted to Tan Tock Seng Hospital, we conducted a retrospective cohort study involving 131 (58.7%) metformin users and 92 (41.3%) non-users. Dengue severity was categorized as dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) in World Health Organization (WHO) 1997 criteria and severe dengue (SD) in WHO 2009 criteria. Multivariable Poisson regression with robust error variance was used to estimate risk ratio (RR). Compared with non-use, metformin use was associated with a decreased risk of developing severe dengue (adjusted risk ratio [aRR] = 0.60, 95% confidence interval [CI]: 0.37-0.98, P = 0.04). Additionally, there was an inverse dose-response relationship (aRR = 0.69, 95% CI: 0.49-0.98, P = 0.04) with dengue severity as classified by WHO 2009 criteria. Use of metformin, however, was not associated with dengue severity based on WHO 1997 criteria; and no dose-response relationship was noted. Our results suggest metformin use could attenuate disease severity in dengue-infected diabetes mellitus individuals. © 2018 The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectantidiabetic agent
dc.subjectmetformin
dc.subjectadult
dc.subjectaged
dc.subjectclassification
dc.subjectcomplication
dc.subjectdose response
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectmiddle aged
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectpathology
dc.subjectretrospective study
dc.subjectrisk assessment
dc.subjectsevere dengue
dc.subjectSingapore
dc.subjectvery elderly
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDose-Response Relationship, Drug
dc.subjectFemale
dc.subjectHumans
dc.subjectHypoglycemic Agents
dc.subjectMale
dc.subjectMetformin
dc.subjectMiddle Aged
dc.subjectRetrospective Studies
dc.subjectRisk Assessment
dc.subjectSevere Dengue
dc.subjectSingapore
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentDEPT OF MEDICINE
dc.description.doi10.1038/s41598-018-21612-6
dc.description.sourcetitleScientific Reports
dc.description.volume8
dc.description.issue1
dc.description.page3344
dc.published.statepublished
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