Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-29752-5
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dc.titleComparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model
dc.contributor.authorStanzel, T.P
dc.contributor.authorDevarajan, K
dc.contributor.authorLwin, N.C
dc.contributor.authorYam, G.H
dc.contributor.authorSchmetterer, L
dc.contributor.authorMehta, J.S
dc.contributor.authorAng, M
dc.date.accessioned2020-10-20T09:45:27Z
dc.date.available2020-10-20T09:45:27Z
dc.date.issued2018
dc.identifier.citationStanzel, T.P, Devarajan, K, Lwin, N.C, Yam, G.H, Schmetterer, L, Mehta, J.S, Ang, M (2018). Comparison of Optical Coherence Tomography Angiography to Indocyanine Green Angiography and Slit Lamp Photography for Corneal Vascularization in an Animal Model. Scientific Reports 8 (1) : 11493. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-29752-5
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178401
dc.description.abstractCorneal neovascularization (CoNV) could be treated by novel anti-angiogenic therapies, though reliable and objective imaging tools to evaluate corneal vasculature and treatment efficacy is still lacking. Optical coherence tomography angiography (OCTA) –currently designed as a retinal vascular imaging system— has been recently adapted for anterior-segment and showed good potential for successful imaging of CoNV. However, further development requires an animal model where parameters can be studied more carefully with histological comparison. Our study evaluated the OCTA in suture-induced CoNV in a rabbit model compared to indocyanine green angiography (ICGA) and slit-lamp photography (SLP). Overall vessel density measurements from OCTA showed good correlation with ICGA (0.957) and SLP (0.992). Vessels density by OCTA was higher than ICGA and SLP (mean = 20.77 ± 9.8%, 15.71 ± 6.28% and 17.55 ± 8.36%, respectively, P < 0.05). OCTA was able to depict CoNV similarly to SLP and ICGA, though it could better detect small vessels. Moreover, the depth and growth of vessels could be assessed using en-face and serial-scans. This study validated the OCTA in a rabbit model as a useful imaging tool for translational studies on CoNV. This may contribute to further studies on OCTA for anterior-segment including serial evaluation of emerging anti-angiogenic therapies. © 2018, The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectcoloring agent
dc.subjectindocyanine green
dc.subjectanimal
dc.subjectcornea
dc.subjectcornea neovascularization
dc.subjectdisease model
dc.subjectfluorescence angiography
dc.subjectfluorescence imaging
dc.subjectLeporidae
dc.subjectmale
dc.subjectoptical coherence tomography
dc.subjectpathology
dc.subjectphotography
dc.subjectprocedures
dc.subjectprospective study
dc.subjectslit lamp
dc.subjectAnimals
dc.subjectColoring Agents
dc.subjectCornea
dc.subjectCorneal Neovascularization
dc.subjectDisease Models, Animal
dc.subjectFluorescein Angiography
dc.subjectIndocyanine Green
dc.subjectMale
dc.subjectOptical Imaging
dc.subjectPhotography
dc.subjectProspective Studies
dc.subjectRabbits
dc.subjectSlit Lamp
dc.subjectTomography, Optical Coherence
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41598-018-29752-5
dc.description.sourcetitleScientific Reports
dc.description.volume8
dc.description.issue1
dc.description.page11493
dc.published.statepublished
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