Please use this identifier to cite or link to this item:
https://doi.org/10.1038/s41598-017-09632-0
DC Field | Value | |
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dc.title | A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration /692/699/3161/1626 /692/699/3161/3175 article | |
dc.contributor.author | Yamashiro, K | |
dc.contributor.author | Mori, K | |
dc.contributor.author | Honda, S | |
dc.date.accessioned | 2020-10-20T09:08:37Z | |
dc.date.available | 2020-10-20T09:08:37Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Yamashiro, K, Mori, K, Honda, S (2017). A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration /692/699/3161/1626 /692/699/3161/3175 article. Scientific Reports 7 (1) : 9196. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-09632-0 | |
dc.identifier.issn | 20452322 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/178306 | |
dc.description.abstract | We conducted a genome-wide association study (GWAS) on the outcome of anti-VEGF treatment for exudative age-related macular degeneration (AMD) in a prospective cohort. Four hundred and sixty-one treatment-naïve AMD patients were recruited at 13 clinical centers and all patients were treated with 3 monthly injections of ranibizumab followed by pro re nata regimen treatment for one year. Genomic DNA was collected from all patients for a 2-stage GWAS on achieving dry macula after the initial treatment, the requirement for an additional treatment, and visual acuity changes during the 12-month observation period. In addition, we evaluated 9 single-nucleotide polymorphisms (SNPs) in 8 previously reported AMD-related genes for their associations with treatment outcome. The discovery stage with 256 patients evaluated 8,480,849 SNPs, but no SNPs showed genome-wide level significance in association with treatment outcomes. Although SNPs with P-values of <5 × 10-6 were evaluated in replication samples of 205 patients, no SNP was significantly associated with treatment outcomes. Among AMD-susceptibility genes, rs10490924 in ARMS2/HTRA1 was significantly associated with additional treatment requirement in the discovery stage (P = 0.0023), and pooled analysis with the replication stage further confirmed this association (P = 0.0013). ARMS2/HTRA1 polymorphism might be able to predict the frequency of injection after initial ranibizumab treatment. © 2017 The Author(s). | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | angiogenesis inhibitor | |
dc.subject | ranibizumab | |
dc.subject | aged | |
dc.subject | allele | |
dc.subject | clinical trial | |
dc.subject | female | |
dc.subject | genetic marker | |
dc.subject | genetic predisposition | |
dc.subject | genetics | |
dc.subject | genome-wide association study | |
dc.subject | human | |
dc.subject | macular degeneration | |
dc.subject | male | |
dc.subject | middle aged | |
dc.subject | multicenter study | |
dc.subject | odds ratio | |
dc.subject | severity of illness index | |
dc.subject | single nucleotide polymorphism | |
dc.subject | treatment outcome | |
dc.subject | very elderly | |
dc.subject | visual acuity | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Alleles | |
dc.subject | Angiogenesis Inhibitors | |
dc.subject | Female | |
dc.subject | Genetic Markers | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Humans | |
dc.subject | Macular Degeneration | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Odds Ratio | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Ranibizumab | |
dc.subject | Severity of Illness Index | |
dc.subject | Treatment Outcome | |
dc.subject | Visual Acuity | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1038/s41598-017-09632-0 | |
dc.description.sourcetitle | Scientific Reports | |
dc.description.volume | 7 | |
dc.description.issue | 1 | |
dc.description.page | 9196 | |
Appears in Collections: | Elements Staff Publications |
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