Please use this identifier to cite or link to this item:
https://doi.org/10.1186/s40413-017-0173-0
DC Field | Value | |
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dc.title | Lactose intolerance and gastrointestinal cow's milk allergy in infants and children - Common misconceptions revisited | |
dc.contributor.author | Heine, R.G | |
dc.contributor.author | Alrefaee, F | |
dc.contributor.author | Bachina, P | |
dc.contributor.author | De Leon, J.C | |
dc.contributor.author | Geng, L | |
dc.contributor.author | Gong, S | |
dc.contributor.author | Madrazo, J.A | |
dc.contributor.author | Ngamphaiboon, J | |
dc.contributor.author | Ong, C | |
dc.contributor.author | Rogacion, J.M | |
dc.date.accessioned | 2020-10-20T05:12:08Z | |
dc.date.available | 2020-10-20T05:12:08Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Heine, R.G, Alrefaee, F, Bachina, P, De Leon, J.C, Geng, L, Gong, S, Madrazo, J.A, Ngamphaiboon, J, Ong, C, Rogacion, J.M (2017). Lactose intolerance and gastrointestinal cow's milk allergy in infants and children - Common misconceptions revisited. World Allergy Organization Journal 10 (1) : 41. ScholarBank@NUS Repository. https://doi.org/10.1186/s40413-017-0173-0 | |
dc.identifier.issn | 19394551 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/178127 | |
dc.description.abstract | Lactose is the main carbohydrate in human and mammalian milk. Lactose requires enzymatic hydrolysis by lactase into D-glucose and D-galactose before it can be absorbed. Term infants express sufficient lactase to digest about one liter of breast milk daily. Physiological lactose malabsorption in infancy confers beneficial prebiotic effects, including the establishment of Bifidobacterium-rich fecal microbiota. In many populations, lactase levels decline after weaning (lactase non-persistence; LNP). LNP affects about 70% of the world's population and is the physiological basis for primary lactose intolerance (LI). Persistence of lactase beyond infancy is linked to several single nucleotide polymorphisms in the lactase gene promoter region on chromosome 2. Primary LI generally does not manifest clinically before 5 years of age. LI in young children is typically caused by underlying gut conditions, such as viral gastroenteritis, giardiasis, cow's milk enteropathy, celiac disease or Crohn's disease. Therefore, LI in childhood is mostly transient and improves with resolution of the underlying pathology. There is ongoing confusion between LI and cow's milk allergy (CMA) which still leads to misdiagnosis and inappropriate dietary management. In addition, perceived LI may cause unnecessary milk restriction and adverse nutritional outcomes. The treatment of LI involves the reduction, but not complete elimination, of lactose-containing foods. By contrast, breastfed infants with suspected CMA should undergo a trial of a strict cow's milk protein-free maternal elimination diet. If the infant is not breastfed, an extensively hydrolyzed or amino acid-based formula and strict cow's milk avoidance are the standard treatment for CMA. The majority of infants with CMA can tolerate lactose, except when an enteropathy with secondary lactase deficiency is present. © 2017 The Author(s). | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | galactose | |
dc.subject | glucose | |
dc.subject | lactase | |
dc.subject | lactose | |
dc.subject | prebiotic agent | |
dc.subject | artificial milk | |
dc.subject | Bifidobacterium | |
dc.subject | breast milk | |
dc.subject | celiac disease | |
dc.subject | child | |
dc.subject | chromosome 2 | |
dc.subject | Crohn disease | |
dc.subject | diagnostic error | |
dc.subject | diet restriction | |
dc.subject | diet supplementation | |
dc.subject | diet therapy | |
dc.subject | differential diagnosis | |
dc.subject | digestion | |
dc.subject | enteropathy | |
dc.subject | feces analysis | |
dc.subject | feces microflora | |
dc.subject | food composition | |
dc.subject | genetic analysis | |
dc.subject | giardiasis | |
dc.subject | human | |
dc.subject | hydrogen breath test | |
dc.subject | hydrolysis | |
dc.subject | infant | |
dc.subject | lactose intolerance | |
dc.subject | milk allergy | |
dc.subject | nutritional status | |
dc.subject | priority journal | |
dc.subject | promoter region | |
dc.subject | protein expression | |
dc.subject | Review | |
dc.subject | single nucleotide polymorphism | |
dc.subject | viral gastroenteritis | |
dc.subject | weaning | |
dc.type | Review | |
dc.contributor.department | PAEDIATRICS | |
dc.description.doi | 10.1186/s40413-017-0173-0 | |
dc.description.sourcetitle | World Allergy Organization Journal | |
dc.description.volume | 10 | |
dc.description.issue | 1 | |
dc.description.page | 41 | |
Appears in Collections: | Elements Staff Publications |
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