Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers10110427
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dc.titleOphiopogonin D, a steroidal glycoside abrogates STAT3 signaling cascade and exhibits anti-cancer activity by causing GSH/GSSG imbalance in lung carcinoma
dc.contributor.authorLee, J.H
dc.contributor.authorKim, C
dc.contributor.authorLee, S.-G
dc.contributor.authorSethi, G
dc.contributor.authorAhn, K.S
dc.date.accessioned2020-10-20T03:29:58Z
dc.date.available2020-10-20T03:29:58Z
dc.date.issued2018
dc.identifier.citationLee, J.H, Kim, C, Lee, S.-G, Sethi, G, Ahn, K.S (2018). Ophiopogonin D, a steroidal glycoside abrogates STAT3 signaling cascade and exhibits anti-cancer activity by causing GSH/GSSG imbalance in lung carcinoma. Cancers 10 (11) : 427. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers10110427
dc.identifier.issn20726694
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/177833
dc.description.abstractNatural medicinal plants are multi-targeted in nature and their anti-cancer activities are also complex and varied, thus requiring a more systematic analysis of their modes of action. Since the activation of signal transducer and activator of transcription 3 (STAT3) is often deregulated in non-small cell lung carcinoma (NSCLC) cells and tissue specimens, its negative regulation can form the basis for identification of targeted therapy. In this report, we analyzed the possible anti-cancer effects of ophiopogonin D (OP-D) and the underlying mechanisms by which OP-D exerts its actions in NSCLC. OP-D exhibited substantial suppressive activity on STAT3 signaling and this effect was found to be mediated via oxidative stress phenomena caused by disturbance in GSH/GSSG ratio. In addition, OP-D induced apoptosis, activated caspase mediated apoptotic cascade and decreased expression of various oncogenic genes. Consistently, OP-D treatment significantly reduced NSCLC tumor growth in preclinical mouse model with via decreasing levels of p-STAT3. OP-D was also found to attenuate the expression of STAT3-regulated anti-apoptosis, cell cycle regulator, and angiogenesis biomarkers. Our findings suggest that OP-D can induce apoptosis and exert anti-tumor effects by inhibition of STAT3 signaling pathways in NSCLC. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectcaspase
dc.subjectglutathione
dc.subjectglutathione disulfide
dc.subjectglycoside
dc.subjectophiopogonin d
dc.subjectSTAT3 protein
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantineoplastic activity
dc.subjectapoptosis
dc.subjectArticle
dc.subjectcancer inhibition
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdrug inhibition
dc.subjectdrug mechanism
dc.subjectenzyme activation
dc.subjectfemale
dc.subjectgene
dc.subjectgene expression
dc.subjecthuman
dc.subjecthuman cell
dc.subjectmouse
dc.subjectnon small cell lung cancer
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectsignal transduction
dc.typeArticle
dc.contributor.departmentPHARMACOLOGY
dc.description.doi10.3390/cancers10110427
dc.description.sourcetitleCancers
dc.description.volume10
dc.description.issue11
dc.description.page427
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