Please use this identifier to cite or link to this item: https://doi.org/10.1210/jc.2018-00475
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dc.titleLow-dose levothyroxine reduces intrahepatic lipid content in patients with type 2 diabetes mellitus and NAFLD
dc.contributor.authorBruinstroop E.
dc.contributor.authorDalan R.
dc.contributor.authorCao Y.
dc.contributor.authorBee Y.M.
dc.contributor.authorChandran K.
dc.contributor.authorCho L.W.
dc.contributor.authorSoh S.B.
dc.contributor.authorTeo E.K.
dc.contributor.authorToh S.-A.
dc.contributor.authorLeow M.K.S.
dc.contributor.authorSinha R.A.
dc.contributor.authorSadananthan S.A.
dc.contributor.authorMichael N.
dc.contributor.authorStapleton H.M.
dc.contributor.authorLeung C.
dc.contributor.authorAngus P.W.
dc.contributor.authorPatel S.K.
dc.contributor.authorBurrell L.M.
dc.contributor.authorLim S.C.
dc.contributor.authorSum C.F.
dc.contributor.authorVelan S.S.
dc.contributor.authorYen P.M.
dc.date.accessioned2020-10-20T01:26:09Z
dc.date.available2020-10-20T01:26:09Z
dc.date.issued2018
dc.identifier.citationBruinstroop E., Dalan R., Cao Y., Bee Y.M., Chandran K., Cho L.W., Soh S.B., Teo E.K., Toh S.-A., Leow M.K.S., Sinha R.A., Sadananthan S.A., Michael N., Stapleton H.M., Leung C., Angus P.W., Patel S.K., Burrell L.M., Lim S.C., Sum C.F., Velan S.S., Yen P.M. (2018). Low-dose levothyroxine reduces intrahepatic lipid content in patients with type 2 diabetes mellitus and NAFLD. Journal of Clinical Endocrinology and Metabolism 103 (7) : 2698 - 2706. ScholarBank@NUS Repository. https://doi.org/10.1210/jc.2018-00475
dc.identifier.issn0021972X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/177756
dc.description.abstractContext Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in patients with type 2 diabetes mellitus (T2DM) and associated with significant morbidity and mortality. Thyroid hormone (TH) increases β-oxidation of fatty acids and decreases intrahepatic lipid content (IHLC) in rodents with NAFLD. Objective We investigated the possibility of low intrahepatic TH concentration in NAFLD and studied the effect of TH treatment in humans. Design/Setting This was a phase 2b single-arm study in six hospitals in Singapore. Intrahepatic thyroid hormone concentrations were measured in rats with induced NAFLD. Patients Euthyroid patients with T2DM and steatosis measured by ultrasonography. Intervention Levothyroxine was titrated to reach a thyroid-stimulating hormone level of 0.34 to 1.70 mIU/L before a 16-week maintenance phase. Main Outcome Measures The primary outcome measure was change in IHLC measured by proton magnetic resonance spectroscopy after treatment. Results Twenty male patients were included in the per-protocol analysis [mean SD: age, 47.8 ± 7.8 years; body mass index (BMI), 30.9 ± 4.4 kg/m 2; baseline IHLC, 13% ± 4%]. After treatment, IHLC was decreased 12% (±SEM, 26%) relative to baseline (absolute change, -2%; 95% CI, -3 to 0; P = 0.046). Small decreases in BMI (P = 0.044), visceral adipose tissue volume (P = 0.047), and subcutaneous adipose tissue volume (P = 0.045) were observed. No significant changes in glucose regulation or lipid profile occurred. Conclusion This study demonstrated the efficacy and safety of low-dose TH therapy for NAFLD in men. TH or TH analogs may be beneficial for this condition. Copyright 2018 Endocrine Society.
dc.publisherOxford University Press
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH)
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEPT OF OBSTETRICS & GYNAECOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1210/jc.2018-00475
dc.description.sourcetitleJournal of Clinical Endocrinology and Metabolism
dc.description.volume103
dc.description.issue7
dc.description.page2698 - 2706
dc.published.statePublished
dc.grant.id1029990
dc.grant.id629025
dc.grant.idKNAW: A3-2
dc.grant.fundingagencyNational Health and Medical Research Council of Australia Grant and scholarship
dc.grant.fundingagencyKoninklijke Nederlandse Akademie van Wetenschappen
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