Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/177573
DC FieldValue
dc.titlePotentially fatal paracetamol overdose and successful treatment with 3 days of intravenous N-acetylcysteine regime - A case report
dc.contributor.authorSule A.A.
dc.contributor.authorTai D.Y.H.
dc.contributor.authorTze C.-C.
dc.contributor.authorDeepa B.
dc.contributor.authorLeow M.
dc.date.accessioned2020-10-16T06:31:07Z
dc.date.available2020-10-16T06:31:07Z
dc.date.issued2006
dc.identifier.citationSule A.A., Tai D.Y.H., Tze C.-C., Deepa B., Leow M. (2006). Potentially fatal paracetamol overdose and successful treatment with 3 days of intravenous N-acetylcysteine regime - A case report. Annals of the Academy of Medicine Singapore 35 (2) : 108 - 111. ScholarBank@NUS Repository.
dc.identifier.issn03044602
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/177573
dc.description.abstractIntroduction: Paracetamol overdose is the most common drug overdose worldwide. To our knowledge, the maximum number of paracetamol tablets ingested reported in the literature is 45 g. Clinical Picture: We describe a 21-year-old patient who acutely ingested 120 tablets, each 500 mg paracetamol (i.e., 60 g equivalent to 1200 mg/kg body weight) in a suicidal attempt. Our patient also drank 2 bottles of codeine-based cough syrup equivalent to 360 mg of codeine. At 6 hours post ingestion, her serum paracetamol level was 207 mg/L. The poor prognostic factors for paracetamol overdose in our patient included massive paracetamol ingestion (confirmed by blood levels), codeine co-ingestion and elevated serum amylase (189 U/L). Treatment: She was treated with a 3-day modified regimen of intravenous N-acetylcysteine. Outcome: The liver function tests and the prothrombin time remained normal over the second and third day of admission and the patient was discharged without complications on the fifth day. Conclusion: From this experience we feel that in very severe paracetamol poisoning, a modified regime of intravenous N-acetylcysteine for 3 days is safe and efficacious.
dc.sourceScopus
dc.subjectCodeine
dc.subjectHyperamylasaemia
dc.subjectIngestion
dc.subjectSuicidal
dc.typeArticle
dc.contributor.departmentMEDICINE
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.sourcetitleAnnals of the Academy of Medicine Singapore
dc.description.volume35
dc.description.issue2
dc.description.page108 - 111
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.