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https://scholarbank.nus.edu.sg/handle/10635/177573
DC Field | Value | |
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dc.title | Potentially fatal paracetamol overdose and successful treatment with 3 days of intravenous N-acetylcysteine regime - A case report | |
dc.contributor.author | Sule A.A. | |
dc.contributor.author | Tai D.Y.H. | |
dc.contributor.author | Tze C.-C. | |
dc.contributor.author | Deepa B. | |
dc.contributor.author | Leow M. | |
dc.date.accessioned | 2020-10-16T06:31:07Z | |
dc.date.available | 2020-10-16T06:31:07Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Sule A.A., Tai D.Y.H., Tze C.-C., Deepa B., Leow M. (2006). Potentially fatal paracetamol overdose and successful treatment with 3 days of intravenous N-acetylcysteine regime - A case report. Annals of the Academy of Medicine Singapore 35 (2) : 108 - 111. ScholarBank@NUS Repository. | |
dc.identifier.issn | 03044602 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/177573 | |
dc.description.abstract | Introduction: Paracetamol overdose is the most common drug overdose worldwide. To our knowledge, the maximum number of paracetamol tablets ingested reported in the literature is 45 g. Clinical Picture: We describe a 21-year-old patient who acutely ingested 120 tablets, each 500 mg paracetamol (i.e., 60 g equivalent to 1200 mg/kg body weight) in a suicidal attempt. Our patient also drank 2 bottles of codeine-based cough syrup equivalent to 360 mg of codeine. At 6 hours post ingestion, her serum paracetamol level was 207 mg/L. The poor prognostic factors for paracetamol overdose in our patient included massive paracetamol ingestion (confirmed by blood levels), codeine co-ingestion and elevated serum amylase (189 U/L). Treatment: She was treated with a 3-day modified regimen of intravenous N-acetylcysteine. Outcome: The liver function tests and the prothrombin time remained normal over the second and third day of admission and the patient was discharged without complications on the fifth day. Conclusion: From this experience we feel that in very severe paracetamol poisoning, a modified regime of intravenous N-acetylcysteine for 3 days is safe and efficacious. | |
dc.source | Scopus | |
dc.subject | Codeine | |
dc.subject | Hyperamylasaemia | |
dc.subject | Ingestion | |
dc.subject | Suicidal | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.sourcetitle | Annals of the Academy of Medicine Singapore | |
dc.description.volume | 35 | |
dc.description.issue | 2 | |
dc.description.page | 108 - 111 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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