Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms19051310
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dc.titleNoncoding RNA: RNA regulatory networks in cancer
dc.contributor.authorChan, J.J
dc.contributor.authorTay, Y
dc.date.accessioned2020-09-14T08:29:27Z
dc.date.available2020-09-14T08:29:27Z
dc.date.issued2018
dc.identifier.citationChan, J.J, Tay, Y (2018). Noncoding RNA: RNA regulatory networks in cancer. International Journal of Molecular Sciences 19 (5) : 1310. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms19051310
dc.identifier.issn1661-6596
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/176205
dc.description.abstractNoncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and has been implicated inmany pathological conditions, especially cancer. The different subclasses of ncRNAs include microRNAs, a class of short ncRNAs; and a variety of long ncRNAs (lncRNAs), such as lincRNAs, antisense RNAs, pseudogenes, and circular RNAs. Many studies have demonstrated the involvement of these ncRNAs in competitive regulatory interactions, known as competing endogenous RNA (ceRNA) networks, whereby lncRNAs can act as microRNA decoys to modulate gene expression. These interactions are often interconnected, thus aberrant expression of any network component could derail the complex regulatory circuitry, culminating in cancer development and progression. Recent integrative analyses have provided evidence that new computational platforms and experimental approaches can be harnessed together to distinguish key ceRNA interactions in specific cancers, which could facilitate the identification of robust biomarkers and therapeutic targets, and hence, more effective cancer therapies and better patient outcome and survival. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
dc.sourceUnpaywall 20200831
dc.subjectcomplementary RNA
dc.subjectcyclin E
dc.subjectcytohesin 1
dc.subjecthigh mobility group A2 protein
dc.subjectlong untranslated RNA
dc.subjectmessenger RNA
dc.subjectmicroRNA
dc.subjectphosphatidylinositol 3,4,5 trisphosphate 3 phosphatase
dc.subjectphosphatidylinositol 4,5 bisphosphate 3 kinase
dc.subjectpyruvate dehydrogenase kinase
dc.subjectRNA H19
dc.subjectSmad7 protein
dc.subjectsomatomedin B
dc.subjectSTAT3 protein
dc.subjecttranscription factor ZEB1
dc.subjecttranscriptome
dc.subjecttyrosinase related protein 1
dc.subjectuntranslated RNA
dc.subjectzinc finger E box binding homeobox 2
dc.subjectlong untranslated RNA
dc.subjectmicroRNA
dc.subjectRNA
dc.subjectRNA, circular
dc.subjecttumor marker
dc.subjectbioinformatics
dc.subjectbreast cancer
dc.subjectcancer growth
dc.subjectcolorectal carcinoma
dc.subjectDNA damage
dc.subjectepithelial mesenchymal transition
dc.subjectgallbladder cancer
dc.subjectgene control
dc.subjectgene expression
dc.subjectglioma
dc.subjecthuman
dc.subjectKRASP1 gene
dc.subjectliver cell carcinoma
dc.subjectmalignant neoplasm
dc.subjectmelanoma
dc.subjectmouth squamous cell carcinoma
dc.subjectNEAT1 gene
dc.subjectnon small cell lung cancer
dc.subjectnonhuman
dc.subjectoncogene
dc.subjectpancreas cancer
dc.subjectphenotype
dc.subjectprotein expression
dc.subjectpseudogene
dc.subjectregulatory RNA sequence
dc.subjectReview
dc.subjectsignal transduction
dc.subjectstomach cancer
dc.subjecttreatment outcome
dc.subjecttumor suppressor gene
dc.subjectTYRP1 gene
dc.subjectupregulation
dc.subjectcarcinogenesis
dc.subjectgene expression profiling
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectneoplasm
dc.subjectRNA transport
dc.subjectBiomarkers, Tumor
dc.subjectCarcinogenesis
dc.subjectGene Expression
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectHumans
dc.subjectMicroRNAs
dc.subjectNeoplasms
dc.subjectPseudogenes
dc.subjectRNA
dc.subjectRNA Transport
dc.subjectRNA, Long Noncoding
dc.typeReview
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.3390/ijms19051310
dc.description.sourcetitleInternational Journal of Molecular Sciences
dc.description.volume19
dc.description.issue5
dc.description.page1310
dc.published.statePublished
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