Please use this identifier to cite or link to this item: https://doi.org/10.3390/molecules25173935
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dc.titleFatty Acid Synthase: An Emerging Target in Cancer
dc.contributor.authorFHU CHEE WAI
dc.contributor.authorAZHAR BIN ALI
dc.date.accessioned2020-09-11T03:30:15Z
dc.date.available2020-09-11T03:30:15Z
dc.date.issued2020-08-28
dc.identifier.citationFHU CHEE WAI, AZHAR BIN ALI (2020-08-28). Fatty Acid Synthase: An Emerging Target in Cancer. Molecules 25 (17) : 3935-3935. ScholarBank@NUS Repository. https://doi.org/10.3390/molecules25173935
dc.identifier.issn1420-3049
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/175794
dc.description.abstract<jats:p>In recent years, lipid metabolism has garnered significant attention as it provides the necessary building blocks required to sustain tumor growth and serves as an alternative fuel source for ATP generation. Fatty acid synthase (FASN) functions as a central regulator of lipid metabolism and plays a critical role in the growth and survival of tumors with lipogenic phenotypes. Accumulating evidence has shown that it is capable of rewiring tumor cells for greater energy flexibility to attain their high energy requirements. This multi-enzyme protein is capable of modulating the function of subcellular organelles for optimal function under different conditions. Apart from lipid metabolism, FASN has functional roles in other cellular processes such as glycolysis and amino acid metabolism. These pivotal roles of FASN in lipid metabolism make it an attractive target in the clinic with several new inhibitors currently being tested in early clinical trials. This article aims to present the current evidence on the emergence of FASN as a target in human malignancies.</jats:p>
dc.publisherMDPI AG
dc.sourceElements
dc.typeReview
dc.date.updated2020-09-10T23:26:20Z
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.3390/molecules25173935
dc.description.sourcetitleMolecules
dc.description.volume25
dc.description.issue17
dc.description.page3935-3935
dc.published.statePublished
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