Please use this identifier to cite or link to this item:
https://doi.org/10.3390/molecules25173935
DC Field | Value | |
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dc.title | Fatty Acid Synthase: An Emerging Target in Cancer | |
dc.contributor.author | FHU CHEE WAI | |
dc.contributor.author | AZHAR BIN ALI | |
dc.date.accessioned | 2020-09-11T03:30:15Z | |
dc.date.available | 2020-09-11T03:30:15Z | |
dc.date.issued | 2020-08-28 | |
dc.identifier.citation | FHU CHEE WAI, AZHAR BIN ALI (2020-08-28). Fatty Acid Synthase: An Emerging Target in Cancer. Molecules 25 (17) : 3935-3935. ScholarBank@NUS Repository. https://doi.org/10.3390/molecules25173935 | |
dc.identifier.issn | 1420-3049 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/175794 | |
dc.description.abstract | <jats:p>In recent years, lipid metabolism has garnered significant attention as it provides the necessary building blocks required to sustain tumor growth and serves as an alternative fuel source for ATP generation. Fatty acid synthase (FASN) functions as a central regulator of lipid metabolism and plays a critical role in the growth and survival of tumors with lipogenic phenotypes. Accumulating evidence has shown that it is capable of rewiring tumor cells for greater energy flexibility to attain their high energy requirements. This multi-enzyme protein is capable of modulating the function of subcellular organelles for optimal function under different conditions. Apart from lipid metabolism, FASN has functional roles in other cellular processes such as glycolysis and amino acid metabolism. These pivotal roles of FASN in lipid metabolism make it an attractive target in the clinic with several new inhibitors currently being tested in early clinical trials. This article aims to present the current evidence on the emergence of FASN as a target in human malignancies.</jats:p> | |
dc.publisher | MDPI AG | |
dc.source | Elements | |
dc.type | Review | |
dc.date.updated | 2020-09-10T23:26:20Z | |
dc.contributor.department | CANCER SCIENCE INSTITUTE OF SINGAPORE | |
dc.description.doi | 10.3390/molecules25173935 | |
dc.description.sourcetitle | Molecules | |
dc.description.volume | 25 | |
dc.description.issue | 17 | |
dc.description.page | 3935-3935 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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2020 Molecules.pdf | 1.37 MB | Adobe PDF | OPEN | Published | View/Download |
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