Please use this identifier to cite or link to this item:
https://doi.org/10.1093/infdis/jiu296
DC Field | Value | |
---|---|---|
dc.title | Small molecule targeting malaria Merozoite surface protein-1 (MSP-1) prevents host invasion of divergent Plasmodial species | |
dc.contributor.author | Chandramohanadas R. | |
dc.contributor.author | Russell B. | |
dc.contributor.author | Liew K. | |
dc.contributor.author | Yau Y.H. | |
dc.contributor.author | Chong A. | |
dc.contributor.author | Liu M. | |
dc.contributor.author | Gunalan K. | |
dc.contributor.author | Raman R. | |
dc.contributor.author | Renia L. | |
dc.contributor.author | Nosten F. | |
dc.contributor.author | Shochat S.G. | |
dc.contributor.author | Dao M. | |
dc.contributor.author | Sasisekharan R. | |
dc.contributor.author | Suresh S. | |
dc.contributor.author | Preiser P. | |
dc.date.accessioned | 2020-09-09T07:25:52Z | |
dc.date.available | 2020-09-09T07:25:52Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Chandramohanadas R., Russell B., Liew K., Yau Y.H., Chong A., Liu M., Gunalan K., Raman R., Renia L., Nosten F., Shochat S.G., Dao M., Sasisekharan R., Suresh S., Preiser P. (2014). Small molecule targeting malaria Merozoite surface protein-1 (MSP-1) prevents host invasion of divergent Plasmodial species. Journal of Infectious Diseases 210 (10) : 1616-1626. ScholarBank@NUS Repository. https://doi.org/10.1093/infdis/jiu296 | |
dc.identifier.issn | 0022-1899 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/175315 | |
dc.description.abstract | Malaria causes nearly 1 million deaths annually. Recent emergence of multidrug resistance highlights the need to develop novel therapeutic interventions against human malaria. Given the involvement of sugar binding plasmodial proteins in host invasion, we set out to identify such proteins as targets of small glycans. Combining multidisciplinary approaches, we report the discovery of a small molecule inhibitor, NIC, capable of inhibiting host invasion through interacting with a major invasion-related protein, merozoite surface protein-1 (MSP-1). This interaction was validated through computational, biochemical, and biophysical tools. Importantly, treatment with NIC prevented host invasion by Plasmodium falciparum and Plasmodium vivax - major causative organisms of human malaria. MSP-1, an indispensable antigen critical for invasion and suitably localized in abundance on the merozoite surface represents an ideal target for antimalarial development. The ability to target merozoite invasion proteins with specific small inhibitors opens up a new avenue to target this important pathogen. © 2014 © The Author 2014. | |
dc.publisher | Oxford University Press | |
dc.source | Unpaywall 20200831 | |
dc.subject | 2 butyl 5 chloro 3 (4 nitro benzyl) 3h imidazole 4 carbaldehyde | |
dc.subject | ligand | |
dc.subject | merozoite surface protein 1 | |
dc.subject | unclassified drug | |
dc.subject | antimalarial agent | |
dc.subject | merozoite surface protein 1 | |
dc.subject | Article | |
dc.subject | binding affinity | |
dc.subject | carboxy terminal sequence | |
dc.subject | computer model | |
dc.subject | controlled study | |
dc.subject | in vitro study | |
dc.subject | merozoite | |
dc.subject | molecular docking | |
dc.subject | nonhuman | |
dc.subject | parasite phenomena and functions | |
dc.subject | Plasmodium falciparum | |
dc.subject | Plasmodium vivax | |
dc.subject | protein analysis | |
dc.subject | protein binding | |
dc.subject | protein localization | |
dc.subject | protein protein interaction | |
dc.subject | sequence alignment | |
dc.subject | species invasion | |
dc.subject | surface plasmon resonance | |
dc.subject | antagonists and inhibitors | |
dc.subject | drug effects | |
dc.subject | endocytosis | |
dc.subject | human | |
dc.subject | isolation and purification | |
dc.subject | Plasmodium falciparum | |
dc.subject | Plasmodium vivax | |
dc.subject | Antimalarials | |
dc.subject | Endocytosis | |
dc.subject | Humans | |
dc.subject | Merozoite Surface Protein 1 | |
dc.subject | Plasmodium falciparum | |
dc.subject | Plasmodium vivax | |
dc.type | Article | |
dc.contributor.department | MICROBIOLOGY AND IMMUNOLOGY | |
dc.contributor.department | DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL) | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | DEAN'S OFFICE (SCIENCE) | |
dc.description.doi | 10.1093/infdis/jiu296 | |
dc.description.sourcetitle | Journal of Infectious Diseases | |
dc.description.volume | 210 | |
dc.description.issue | 10 | |
dc.description.page | 1616-1626 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1093_infdis_jiu296.pdf | 768.5 kB | Adobe PDF | OPEN | None | View/Download |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.