Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-017-16634-5
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dc.titleUnraveling the molecular mechanism of photosynthetic toxicity of highly fluorescent silver nanoclusters to Scenedesmus obliquus
dc.contributor.authorZhang, L
dc.contributor.authorGoswami, N
dc.contributor.authorXie, J
dc.contributor.authorZhang, B
dc.contributor.authorHe, Y
dc.date.accessioned2020-09-09T03:16:34Z
dc.date.available2020-09-09T03:16:34Z
dc.date.issued2017
dc.identifier.citationZhang, L, Goswami, N, Xie, J, Zhang, B, He, Y (2017). Unraveling the molecular mechanism of photosynthetic toxicity of highly fluorescent silver nanoclusters to Scenedesmus obliquus. Scientific Reports 7 (1) : 16432. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-017-16634-5
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/175092
dc.description.abstractWhile the discovery of numerous attractive properties of silver at the nanoscale has increased their demand in many sectors including medicine, optics, sensing, painting and cosmetics, it has also raised wide public concerns about their effect on living organisms in aquatic environment. Despite the continuous effort to understand the various aspects of the toxicity of silver nanomaterials, the molecular level understanding on their cytotoxicity mechanism to biological organisms has remained unclear. Herein, we demonstrated the underlying mechanism of the photosynthetic toxicity against green algae namely, Scenedesmus obliquus by using an emerging silver nanomaterial, called silver nanoclusters (defined as r-Ag NCs). By exploiting the unique fluorescence properties of r-Ag NCs along with various other analytical/biological tools, we proposed that the photosynthetic toxicity of r-Ag NCs was largely attributed to the "joint-Toxicity" effect of particulate form of r-Ag NCs and its released Ag+, which resulted in the disruption of the electron transport chain of light reaction and affected the content of key enzymes (RuBP carboxylase/ oxygenase) of Calvin cycle of algae cells. We believe that the present study can also be applied to the assessment of the ecological risk derived from other metal nanoparticles. © 2017 The Author(s).
dc.sourceUnpaywall 20200831
dc.subjectchlorophyll
dc.subjectmetal nanoparticle
dc.subjectsilver
dc.subjectdrug effect
dc.subjectfluorescence
dc.subjectgene expression profiling
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectphotosynthesis
dc.subjectreproducibility
dc.subjectScenedesmus
dc.subjectultrastructure
dc.subjectultraviolet spectrophotometry
dc.subjectChlorophyll
dc.subjectFluorescence
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation
dc.subjectMetabolic Networks and Pathways
dc.subjectMetal Nanoparticles
dc.subjectPhotosynthesis
dc.subjectReproducibility of Results
dc.subjectScenedesmus
dc.subjectSilver
dc.subjectSpectrophotometry, Ultraviolet
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.contributor.departmentNUS ENVIRONMENTAL RESEARCH INSTITUTE
dc.description.doi10.1038/s41598-017-16634-5
dc.description.sourcetitleScientific Reports
dc.description.volume7
dc.description.issue1
dc.description.page16432
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