Please use this identifier to cite or link to this item:
https://doi.org/10.3390/nu10111685
DC Field | Value | |
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dc.title | The Relationship between Generalized and Abdominal Obesity with Diabetic Kidney Disease in Type 2 Diabetes: A Multiethnic Asian Study and Meta-Analysis | |
dc.contributor.author | Man, R.E.K | |
dc.contributor.author | Gan, A.T.L | |
dc.contributor.author | Fenwick, E.K | |
dc.contributor.author | Gupta, P | |
dc.contributor.author | Wong, M.Y.Z | |
dc.contributor.author | Wong, T.Y | |
dc.contributor.author | Tan, G.S.W | |
dc.contributor.author | Teo, B.W | |
dc.contributor.author | Sabanayagam, C | |
dc.contributor.author | Lamoureux, E.L | |
dc.date.accessioned | 2020-09-09T03:05:33Z | |
dc.date.available | 2020-09-09T03:05:33Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Man, R.E.K, Gan, A.T.L, Fenwick, E.K, Gupta, P, Wong, M.Y.Z, Wong, T.Y, Tan, G.S.W, Teo, B.W, Sabanayagam, C, Lamoureux, E.L (2018). The Relationship between Generalized and Abdominal Obesity with Diabetic Kidney Disease in Type 2 Diabetes: A Multiethnic Asian Study and Meta-Analysis. Nutrients 10 (11). ScholarBank@NUS Repository. https://doi.org/10.3390/nu10111685 | |
dc.identifier.issn | 20726643 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/175033 | |
dc.description.abstract | This study examined the associations of body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR) and waist-height ratio (WHtR) with diabetic kidney disease (DKD) in a clinical sample of Asian patients with type 2 diabetes (T2DM); substantiated with a meta-analysis of the above associations. We recruited 405 patients with T2DM (mean (standard deviation (SD)) age: 58 (7.5) years; 277 (68.4%) male; 203 (50.1%) with DKD) from a tertiary care centre in Singapore. DKD was defined as urinary albumin-creatinine ratio >3.3 mg/mmoL and/or estimated glomerular filtration rate <60 mL/min/1.73 m². All exposures were analysed continuously and categorically (World Health Organization cut-points for BMI and WC; median for WHR and WHtR) with DKD using stepwise logistic regression models adjusted for traditional risk factors. Additionally, we synthesized the pooled odds ratio of 18 studies (N = 19,755) in a meta-analysis of the above relationships in T2DM. We found that overweight and obese persons (categorized using BMI) were more likely to have DKD compared to under/normal weight individuals, while no associations were found for abdominal obesity exposures. In meta-analyses however, all obesity parameters were associated with increased odds of DKD. The discordance in our abdominal obesity findings compared to the pooled analyses warrants further validation via longitudinal cohorts. | |
dc.source | Unpaywall 20200831 | |
dc.subject | abdominal obesity | |
dc.subject | aged | |
dc.subject | Asian continental ancestry group | |
dc.subject | body mass | |
dc.subject | diabetic nephropathy | |
dc.subject | ethnic group | |
dc.subject | female | |
dc.subject | human | |
dc.subject | male | |
dc.subject | meta analysis | |
dc.subject | middle aged | |
dc.subject | non insulin dependent diabetes mellitus | |
dc.subject | risk factor | |
dc.subject | Singapore | |
dc.subject | waist circumference | |
dc.subject | waist hip ratio | |
dc.subject | waist to height ratio | |
dc.subject | Aged | |
dc.subject | Asian Continental Ancestry Group | |
dc.subject | Body Mass Index | |
dc.subject | Diabetes Mellitus, Type 2 | |
dc.subject | Diabetic Nephropathies | |
dc.subject | Ethnic Groups | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Obesity, Abdominal | |
dc.subject | Risk Factors | |
dc.subject | Singapore | |
dc.subject | Waist Circumference | |
dc.subject | Waist-Height Ratio | |
dc.subject | Waist-Hip Ratio | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.3390/nu10111685 | |
dc.description.sourcetitle | Nutrients | |
dc.description.volume | 10 | |
dc.description.issue | 11 | |
Appears in Collections: | Elements Staff Publications |
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