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Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep38597
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dc.titleUnlocking bat immunology: Establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages
dc.contributor.authorZhou P.
dc.contributor.authorChionh Y.T.
dc.contributor.authorIrac S.E.
dc.contributor.authorAhn M.
dc.contributor.authorJia Ng J.H.
dc.contributor.authorFossum E.
dc.contributor.authorBogen B.
dc.contributor.authorGinhoux F.
dc.contributor.authorIrving A.T.
dc.contributor.authorDutertre C.-A.
dc.contributor.authorWang L.-F.
dc.date.accessioned2020-09-09T01:22:09Z
dc.date.available2020-09-09T01:22:09Z
dc.date.issued2016
dc.identifier.citationZhou P., Chionh Y.T., Irac S.E., Ahn M., Jia Ng J.H., Fossum E., Bogen B., Ginhoux F., Irving A.T., Dutertre C.-A., Wang L.-F. (2016). Unlocking bat immunology: Establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages. Scientific Reports 6 : 38597. ScholarBank@NUS Repository. https://doi.org/10.1038/srep38597
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/174908
dc.description.abstractBats carry and shed many emerging infectious disease agents including Ebola virus and SARS-like Coronaviruses, yet they rarely display clinical symptoms of infection. Bat epithelial or fibroblast cell lines were previously established to study the bat immune response against viral infection. However, the lack of professional immune cells such as dendritic cells (DC) and macrophages has greatly limited the significance of current investigations. Using Pteropus alecto (P. alecto) GM-CSF plus IL4, FLT3L and CSF-1, we successfully generated bat bone marrow-derived DC and macrophages. Cells with the phenotype, morphology and functional features of monocyte-derived DC, bona fide DC or macrophages were obtained in GM-CSF/IL4, FLT3L or CSF-1 cultures, respectively. The successful generation of the first bat bone marrow-derived immune cells paves the way to unlocking the immune mechanisms that confer host resilience to pathogens in bats. © The Author(s) 2016.
dc.publisherNature Publishing Group
dc.sourceUnpaywall 20200831
dc.subjectbiological marker
dc.subjectcytokine
dc.subjectanimal
dc.subjectbat
dc.subjectdendritic cell
dc.subjectimmunity
dc.subjectimmunology
dc.subjectimmunophenotyping
dc.subjectinnate immunity
dc.subjectmacrophage
dc.subjectmetabolism
dc.subjectphagocytosis
dc.subjectphenotype
dc.subjectT lymphocyte
dc.subjectAnimals
dc.subjectBiomarkers
dc.subjectChiroptera
dc.subjectCytokines
dc.subjectDendritic Cells
dc.subjectImmunity
dc.subjectImmunity, Innate
dc.subjectImmunophenotyping
dc.subjectMacrophages
dc.subjectPhagocytosis
dc.subjectPhenotype
dc.subjectT-Lymphocytes
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentMICROBIOLOGY AND IMMUNOLOGY
dc.description.doi10.1038/srep38597
dc.description.sourcetitleScientific Reports
dc.description.volume6
dc.description.page38597
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