Please use this identifier to cite or link to this item:
https://doi.org/10.18632/oncotarget.17703
DC Field | Value | |
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dc.title | Real time near-infrared Raman spectroscopy for the diagnosis of nasopharyngeal cancer | |
dc.contributor.author | Ming L.C. | |
dc.contributor.author | Gangodu N.R. | |
dc.contributor.author | Loh T. | |
dc.contributor.author | Zheng W. | |
dc.contributor.author | Wang J. | |
dc.contributor.author | Lin K. | |
dc.contributor.author | Zhiwei H. | |
dc.date.accessioned | 2020-09-09T01:19:40Z | |
dc.date.available | 2020-09-09T01:19:40Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Ming L.C., Gangodu N.R., Loh T., Zheng W., Wang J., Lin K., Zhiwei H. (2017). Real time near-infrared Raman spectroscopy for the diagnosis of nasopharyngeal cancer. Oncotarget 8 (30) : 49443-49450. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.17703 | |
dc.identifier.issn | 19492553 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/174896 | |
dc.description.abstract | Near-infrared (NIR) Raman spectroscopy has been investigated as a tool to differentiate nasopharyngeal cancer (NPC) from normal nasopharyngeal tissue in an ex-vivo setting. Recently, we have miniaturized the fiber-optic Raman probe to investigate its utility in real time in-vivo surveillance of NPC patients. A posterior probability model using partial linear square (PLS) mathematical technique was constructed to verify the sensitivity and specificity of Raman spectroscopy in diagnosing NPC from post-irradiated and normal tissue using a diagnostic algorithm from three significant latent variables. NIR-Raman signals of 135 sites were measured from 79 patients with either newly diagnosed NPC (N = 12), post irradiated nasopharynx (N = 37) and normal nasopharynx (N = 30). The mean Raman spectra peaks identified differences at several Raman peaks at 853 cm -1 , 940 cm -1 , 1078 cm -1 , 1335 cm -1 , 1554 cm -1 , 2885 cm -1 and 2940 cm -1 in the three different nasopharyngeal conditions. The sensitivity and specificity of distinguishing Raman signatures among normal nasopharynx versus NPC and post-irradiated nasopharynx versus NPC were 91% and 95%; and 77% and 96% respectively. Real time near-infrared Raman spectroscopy has a high specificity in distinguishing malignant from normal nasopharyngeal tissue in vivo, and may be investigated as a novel non-invasive surveillance tool in patients with nasopharyngeal cancer. © Ming et al. | |
dc.publisher | Impact Journals LLC | |
dc.source | Unpaywall 20200831 | |
dc.subject | adult | |
dc.subject | Article | |
dc.subject | cancer staging | |
dc.subject | controlled study | |
dc.subject | diagnostic test accuracy study | |
dc.subject | female | |
dc.subject | follow up | |
dc.subject | human | |
dc.subject | human tissue | |
dc.subject | major clinical study | |
dc.subject | male | |
dc.subject | mathematical analysis | |
dc.subject | nasopharynx | |
dc.subject | nasopharynx cancer | |
dc.subject | nuclear magnetic resonance imaging | |
dc.subject | Raman spectrometry | |
dc.subject | sensitivity and specificity | |
dc.subject | tumor biopsy | |
dc.type | Article | |
dc.contributor.department | OTOLARYNGOLOGY | |
dc.description.doi | 10.18632/oncotarget.17703 | |
dc.description.sourcetitle | Oncotarget | |
dc.description.volume | 8 | |
dc.description.issue | 30 | |
dc.description.page | 49443-49450 | |
Appears in Collections: | Elements Staff Publications |
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10_18632_oncotarget_17703.pdf | 1.3 MB | Adobe PDF | OPEN | None | View/Download |
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