Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.17633
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dc.titleHuman mesenchymal stem cells preferentially migrate toward highly oncogenic human hepatocellular carcinoma cells with activated EpCAM signaling
dc.contributor.authorEndaya B
dc.contributor.authorGuan S.P.
dc.contributor.authorNewman J.P.
dc.contributor.authorHuynh H.
dc.contributor.authorSia K.C.
dc.contributor.authorChong S.T.
dc.contributor.authorKok C.Y.L.
dc.contributor.authorChung A.Y.F.
dc.contributor.authorLiu B.B.
dc.contributor.authorHui K.M.
dc.contributor.authorLam P.Y.P.
dc.date.accessioned2020-09-09T01:19:11Z
dc.date.available2020-09-09T01:19:11Z
dc.date.issued2017
dc.identifier.citationEndaya B, Guan S.P., Newman J.P., Huynh H., Sia K.C., Chong S.T., Kok C.Y.L., Chung A.Y.F., Liu B.B., Hui K.M., Lam P.Y.P. (2017). Human mesenchymal stem cells preferentially migrate toward highly oncogenic human hepatocellular carcinoma cells with activated EpCAM signaling. Oncotarget 8 (33) : 54629-54639. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.17633
dc.identifier.issn19492553
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/174894
dc.description.abstractThe epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein that is regarded as one of the markers for tumor initiating cells (TIC) in human hepatocellular carcinoma (HCC). Much work has been directed towards targeting these TICs as a mean of placing these master regulators of cell proliferation and drug resistance under control. Human bone marrow-derived mesenchymal stem cells are known to exhibit an innate property of tumor tropism. However, the possible relationship between MSC and TIC is not well understood. In this study, we show that MSC migration to HCC can be effectively inhibited by TACE and ?-secretase inhibitors that stop the activation of EpCAM signaling event. Silencing of EpCAM expression through siRNA and antibody approaches also resulted in impaired MSC migration. By contrast, increase levels of EpICD proteins in HCC cells and HCC mouse xenografts resulted in enhanced MSC migration. Taken together, these findings show that MSC is drawn to the more oncogenic population of HCC, and could potentially serve as a cell-based carrier of therapeutic genes to target EpICD-enriched hepatic tumor cells. © Endaya et al.
dc.publisherImpact Journals LLC
dc.sourceUnpaywall 20200831
dc.subjectepithelial cell adhesion molecule
dc.subjectgamma secretase inhibitor
dc.subjectsmall interfering RNA
dc.subjecttumor necrosis factor alpha converting enzyme inhibitor
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcell migration
dc.subjectcontrolled study
dc.subjectembryo
dc.subjecthepatocellular carcinoma cell line
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectliver carcinogenesis
dc.subjectliver cell carcinoma
dc.subjectmesenchymal stem cell
dc.subjectmouse
dc.subjectnonhuman
dc.subjectprotein expression
dc.subjectsignal transduction
dc.subjecttumor xenograft
dc.typeArticle
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.description.doi10.18632/oncotarget.17633
dc.description.sourcetitleOncotarget
dc.description.volume8
dc.description.issue33
dc.description.page54629-54639
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